The Clinical Research Of Non-motor Symptoms Of Parkinson’s Disease Treated By Cistanche Particles

Objective:Parkinson’s disease (Parkinson’s disease, PD) in addition to a significant movement disorders symptoms, there are relatively secretive non-motor symptoms. Since the non-motor symptoms of the disease often throughout the entire process, and seriously affect the quality of life of PD patients, researchers in recent years gradually into view, while the non-motor symptoms of PD treatment is to become a hot topic. Due to the current Western medicine poor efficacy in the treatment of non-motor symptoms, some drugs can even aggravate some non-motor symptoms, while Chinese medicine to improve such symptoms have a certain effect, and broad prospects. Cistanche particles are instructors on the basis of theoretical research, combined with years of clinical experience in the treatment of Parkinson’s disease summarizes out, preliminary clinical observation, the drug has some effect in the treatment of non-motor symptoms of Parkinson’s disease. To further understand the clinical efficacy of cistanche particles Parkinson’s disease, the establishment of this project, the application of internationally recognized diagnostic criteria for Parkinson’s disease, the efficacy of disease classification criteria and standards observed cistanche particles particles non-motor symptoms in Parkinson’s disease clinical efficacy and the effect of delaying disease progression, drug treatment laid replenishing kidney theoretical and clinical basis of Parkinson’s disease.Method:Select 2014.12-2015.12 during treatment in the Third Affiliated Hospital of Nanjing University of Traditional Chinese encephalopathy outpatient and 60 inpatient PD patients, the use of randomized manner, divided into treatment group and control group (n= 30), the treatment group (at the same time taking cistanche particles and anti-Parkinson medicine) and control group (single-serving anti-Parkinson medicine). Treatment groups were evaluated for efficacy after 3 months, compared to non-motor symptoms before and after treatment Scale (NMSS) score, Parkinson’s Disease Quality of Life Questionnaire -39 (PDQ-39) score, unified Parkinson’s disease rating scale (UPDRS) scores, Hoehn & Yahr (HY) grading scale to assess efficacy. All data SPSS 17.0 statistical software for statistical analysis.Result:Before and after treatment, compared two groups of patients MMSS Scale score, statistical efficiency obtained, the treatment group was 66.67%, the control group was 10.00%, the efficacy of two non-motor symptoms obvious difference was statistically significant (P <0.05); the extent of the treatment group improved non-motor symptoms than the control group, confirming cistanche particles can improve the non-motor symptoms in PD patients. In terms of quality of life, in patients treated with PDQ-39 score fell by an average 8.9 points, while the control group, the average score dropped 0.3 points, Comparison of two groups was statistically significant (P<0.05), showed cistanche particles can significantly improve PD patients Quality of Life. In motor symptoms, the treatment group UPDRS score was no significant difference before and after treatment, indicating cistanche particles to improve motor symptoms useless; although the treatment group UPDRS scores have dropped to a certain extent, but compared with the control group, the difference was not statistically significance (P> 0.05), said Minga clothing cistanche granule on motor symptoms therapeutic effect compared with simply taking medicine no obvious advantage.