| Purpose:Systemic lupus erythematosus (Systemic lupus erythematosus, called SLE) is a systemic autoimmune disease. More often in women of childbearing age. Is generally believed that the incidence of genetic predisposition, sex hormones and other environmental factors, lesions often involving multiple organs, tissues. Its prolonged course, mostly chronic clinical course and higher mortality. Western cause of systemic lupus erythematosus, pathology and clinical manifestations varied systematically understanding, which uses corticosteroids, immunosuppressive agents, non-steroidal anti-inflammatory drugs and antimalarial treatment, side effects obvious, withdrawal after easy to produce rebound, the effect is not ideal. By observing and analyzing a large number of cases, found that the basic pathogenesis of systemic lupus erythematosus is the liver and kidney-oriented, heat stasis blockage as the standard, heat stasis blockage is an important part of the pathogenesis. Clinical common in systemic lupus erythematosus, acute active stage, so treatment should be temporary as the first, using the method of cooling blood, stasis in treating systemic deficiency heat syndrome, significantly improving clinical outcomes.The main purpose of this study:1, stasis fever machine theory applied in the treatment of systemic lupus erythematosus theoretical basis.2, observe the clinical effect of cooling blood method in treating systemic deficiency heat stasis syndrome.3, clinical cooling circulation method in the clinical application of systemic lupus erythematosus renal impairment acute active stage.method: Choose between January 2014 to December 2015, Jiangsu Provincial Hospital Division of Rheumatology inpatient and outpatient systemic lupus erythematosus patients with 60 cases of kidney damage, and by the TCM heat syndrome and stasis of kidney disease is active (SLEDAI score> 4) were randomly divided into 2 groups of 30 patients, Western medicine treatment group received oral prednisone and intravenous cyclophosphamide; combined treatment group increased cooling circulation method of oral medicine in western medicine on the basis of a course 3 months. Were observed before treatment, after 6 weeks of treatment, the clinical efficacy of 12 weeks, TCM syndrome after treatment; SLEDAI integral; hormone withdrawal comparative reduction; Syndrome total score change; the main symptoms improved after treatment (sustained fever, irritability, thirst, zygomatic red erythema, coma, mouth ulcers, urine short red, bleeding, hair loss, joint pain); and to assess degree of joint swelling and pain VAS scores of patients; observed change detection indicators (blood count, erythrocyte sedimentation rate, complement C3, C4, liver and kidney function, ds-DNA quantitation, ANA quantitative, antinuclear antibody spectrum,24h urinary protein quantitation, etc.).result:1, integrative medicine treatment group assessment effective than the control group, with a statistically significant difference.2, two groups of patients after treatment SLEDAI scores were compared with before treatment were significantly different (P<0.05), treatment in the combination therapy group of patients with SLEDAI scores decreased faster than the control group at the end of treatment to groups patients with SLEDAI score difference was statistically significant (P<0.05).3, the amount of hormone treatment in two groups of patients Withdrawal, compared with a statistically significant difference (P<0.05) before treatment and after treatment dosage. Integrative amount of hormone-treated patients than the control group after treatment, withdrawal reduction was higher, the difference was statistically significant (P<0.05).4, the combination therapy group were Syndrome changes in total score than the control group, the difference was statistically significant (P<0.05).5, two groups of patients after treatment the main symptoms were improved, but the combination therapy group improved more obvious symptoms, persistent fever, irritability, thirst, more symptoms of erythema zygomatic red urine short red, joint pain frequency and level control compared with a statistically significant difference (P<0.05).6, treatment of patients in both groups VAS scores contrast, patients in the combination therapy group VAS scores than the control group, the difference was statistically significant (P<0.05).7, change detection indicators:the combination therapy group, urinary protein excretion was significantly lower than the control group, the difference was significant, P<0.05, immunological and biochemical indicators ESR compared with the control group was significantly P<0.05; WBC, PLT, C3, C4 showed a rising trend, two groups showed no significant difference between the value of the treatment of six weeks, in addition to C3, the Integrative Medicine index value WBC, PLT, C4 and other treatment group after 6 weeks of treatment were significantly higher in the control group, the difference was significant, P<0.05. ds-DNA quantitation, ANA quantitative, antinuclear antibody profile did not change significantly before and after treatment.in conclusion:Integrative Medicine clinical efficacy, the efficacy of TCM symptoms, related laboratory tests (blood count, erythrocyte sedimentation rate, complement C3, C4, liver and kidney function, ds-DNA quantitation, ANA quantitative, antinuclear antibody spectrum,24h urine protein) in the treatment group clinical symptoms (persistent fever, irritability, thirst, zygomatic red erythema, coma, mouth ulcers, urine short red, bleeding, hair loss, joint pain), SLEDAI integral, VAS score, hormone withdrawal reduction, TCM symptom total score regard, the combination therapy group was significantly better than western medicine group. Show cooling blood stasis in treating systemic deficiency heat syndrome, a significant effect, worthy of clinical application. |
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