The Clinical Efficacy Analysis Of Radiotherapy Combined With Temozolomide In Malignant Glioma Patients

Objective:Study the efficacy of postoperative radiation therapy combined with temozolomide chemotherapy for malignant glioma.Methods:Selected 40 cases of pathological diagnosis for WHO III and IV level malignant glioma patients treated in Department of Neurosurgeryof the Third Affiliated Hospital of Kunming Medical University from 2011 to 2013.According to the postoperative therapy plan,all patients were divided into two groups,i.e. radiation therapy combined with temozolomide group (RT+TMZ group) 22 cases and radiation therapy combined with Nimustine and Cisplatin group (RT+ACNU+DDP group) 18 cases, the efficacy and side effects were retrospectively analyzed..Results:Radiation therapy with temozolomide group and radiotherapy with Nimustine and Cisplatin group:1 year survival rates was 63.6% and 61.1%, the difference was not statistically significant (P>0.05); 2 years survival rates was 22.7% and 0 respectively,the difference is statistically significant (P<0.05); the average survival time and median survival period were 10.944,16.258 months and 13,11 months respectively, the differences were statistically significant(P<0.05). By the Cox multivariate analyses,there is a certain relationship between postoperative adjuvant therapy and pathological grade and the prognosis of patients with malignant gliomas, and there was no significant correlation between the age and KPS score and the prognosis of patients with malignant gliomas.Conclusions:The clinical efficacy of radiotherapy combined with chemotherapy for patients with malignant glioma is better than that of radiotherapy combined with Nimustine and Cisplatin.Patients with 2 years survival rate was significantly improved, the average survival time of patients and the median survival period was extended and the occurrence rate of adverse reactions of radiotherapy combined with temozolomide chemotherapy is low, which is relieved after symptomatic treatment, with better security. There are obvious advantages in the treatment of patients, it is worthy of clinical application.