Correlations Between The Values Of ADC And Dynamic Contrast-enhanced Quantitative Parameters Of Clinical Pathological Features In Rectal Cancer

Objective: Investigate the correlations between the values of ADC and dynamic contrast-enhanced quantitative parameters(Ktrans, Ve, Kep) of 3.0T MR and clinical pathological features of rectal cancer.Methods: Collecting 82 cases of patients with rectal cancer, the clinical time is between March 2014 and June 2015, and the clinic location is in gansu provincial hospital. The male patients and female patients were 50 and 32 cases, respectively; their ages are from 28 to 81 year old. And their average age is(61.5±12.7); all rectal cancer patients underwent preoperative MRI, DWI and DCE-MRI examination. And all did not have radiotherapy and chemotherapy, only achieving the results of the relevant cases after the surgery, and all cancer are adenocarcinoma. Pathological results included 13 cases of high differentiation, 59 cases of middle differentiation and 10 cases of poorly differentiated; the stages A, B, C, D of Dukes are 18, 39, 18, 7 cases, respective; with and without lymph node metastasis are 26, 56 cases, respectively. Though the retrospectively analysis of DWI and DCE-MRI images of eighty-two rectal cancer patients confirmed by pathology, we obtained the values of ADC and quantitative parameters of Ktrans、Kep、Ve and investigated the correlations between quantitative parameterstake and tumor differentiation, Duke staging and lymph node metastasis.Results: The ADC value of rectal cancer decreased with the decrease of tumor differentiation and the increase of Dukes stage, which has the statistical significance. The relevant parameter values of quantitative parameters increased with the decrease of tumor differentiation(P<0.01); And the Ktrans and Kep values showed a rising trend along with the increasing from A stage to D stage of Duke staging(P<0.01); through the data analysis between the quantitative parameters and lymph node metastasis, there was a certain correlation between the quantitative parameter values and lymph node metastasis(P<0.01).Conclusions: Not only the ADC values of DWI, but also quantitative parameters(Ktrans, Ve and Kep) of DCE-MRI has some correlations with clinical pathology features of rectal cancer. And these parameters not only can be used as biological markers for rectal cancer image, but also can provide a reference value for predicting the deterioration of tumor.