The Clinical Study And Analysis Of The Bone Mineral Density Of The Kidney Transplantation Recipients

ObjectiveThe bone metabolism of the kidney transplantation recipients is affected by a number of factors. The most common of osteoporosis is glucocorticoid-induced osteoporosis for kidney transplantation recipients. The objective of our research is to discuss and analyze the present situations, for providing more guidance for the clinical diagnosis and treatment of glucocorticoid-induced osteoporosis for kidney transplantation recipients.MethodsThe study include 180 cases of kidney transplantation recipients form March 2015 to November 2015 in our hospital for treatment,among which 98 were male, 82 were female.Age at inclusion(mean±SD) of male was 42.27 ± 10.904, and age at inclusion(mean±SD)of female was 49.55 ± 10.834. Bone mineral density of L1-L4 and the left proximal femur(including the neck、the torch and the ward’s triangle) of kidney transplantation recipients was detected by dual energy X-ray absorptiometry(DEXA Norland,USA). We also monitored the routine blood count, liver and kidney functions, serum biochemical levels,the blood concentration of the FK506 and Cyclosporin, parathyroid hormone and vitamin D of kidney transplantation recipients. All data were analyzed by the Statistical Package for the Social Sciences for Windows version 19.0.Results1. The study include 180 cases of kidney transplantation recipients, among which 98 were male, 82 were female. Age at inclusion(mean±SD) of male was 42.27 ± 10.904, and age at inclusion(mean±SD) of female was 49.55 ± 10.834. The body mass index had no statistical difference, the t test shows that the lumbar spine and femoral neck bone mineral density of female kidney transplantation recipients were significantly lower than male of kidney transplantation recipients of the same age group(P < 0.05).2. Forty-six per cent of male of kidney transplantation recipients were osteopenia,twenty per cent of male of kidney transplantation recipients were osteoporosis. Forty per cent of female of kidney transplantation recipients were osteopenia, twenty-nine per cent of female of kidney transplantation recipients were osteoporosis. Serum creatinine,urea nitrogen and uric acid level of kidney transplantation recipients above normal.3. Mono factor analysis of variance showed that different months after transplantation influenced different sites of bone mineral density of kidney transplantation recipients(P <0.05). So it is in male and female kidney transplantation recipients(P < 0.05).4. Mono factor analysis of variance showed that different ages influenced different sites of bone mineral density of kidney transplantation recipients(P < 0.05). So it is in male and female kidney transplantation recipients(P < 0.05).5. The bone mineral density of L1, L2, L3,femoral neck and femur triangle area of postmenopausal female of kidney transplantation recipients were significantly lower than premenopausal female of kidney transplantation recipients(P < 0.05).Conclusions1.Kidney transplantation recipients are more likely to develop osteoporosis, and female kidney transplantation recipients are more likely than male kidney transplantation recipients to develop osteoporosis.2.Postmenopausal female of kidney transplantation recipients are more likely to bone mass loss than premenopausal female of kidney transplantation recipients.3.The bone mineral density of kidney transplantation recipients decreased while the ages and months after transplant increased, and there was difference in different ages and months after transplant increased. This phenomenon exists in different sex in varying degrees. We should pay attention to both the bone mineral density of male and female of kidney transplantation recipients.