The Correlation Between The Advanced Glycation End-products And Varying Degrees Of Age-related Cataract

[Objective]To explore the differences between the advanced glycation end-products and varying degrees of age-related cataract by detecting the content of serum AGEs.[Methods]Fasting peripheral venous blood was collected from 50 normal volunteers and 360 varying degrees of age-related cataract patients,according to the U.S. national eye institute funded lens opacity classification method â…¢,age-related cataract was divided into cortical cataract and nuclear cataract, and the cortical cataract group was divided into C1, C2, C3, C4 and C5 five subgroups, nuclear cataract group was divided into N1, N2 and N3 three subgroups. Flow injection assay technique was used to detect the content of their serum AGEs. Then the correlation were analyzed between AGEs and varying degrees of age-related cataract.[Results]The serum AGEs level of all subgroup was higher than the control group (P<0.05). Serum AGEs level of cortical cataract group was showed C5> C4>C3> C2 and C5> C4>C3> C1 (P< 0.05), comparing C1 with C2 two subgroups, no significant differences(P> 0.05);and serum AGEs level of nuclear cataract was showed N3> N2> N1 (P<0.05). After adjusting various factors, linear regression and correlation showed that serum AGEs was correlated positively with varying degree of age-related cataract (cortical cataract group r=0.82,p<0.01;nuclear cataract group r=0.94,p<0.01).[Conclusion]Serum AGEs with varying degrees of age-related cataracts are positively correlated.