The Study Of Hepatitis B Virus Reactivation In Hepatocellular Carcin-oma Patients Undergoing Transcatheter Arterial Chemoembolization Therapy

Objective: To study the changes of serum levels and the influencing factors of hepatitis B virus DNA in patients with hepatocellular carcinoma aroud transarterial chemoembolization(TACE).Methods: Collected during October 2014 to August 2015, 55 cases related HBV hepatocellular carcinoma, in sex, age, tumor size, liver function, tumor mark alphafetoprotein(AFP), preoperative HBV DNA load, portal vein tumor thrombus, with amount of l-ipiodol and surgical operation method etc. as factors were statistically analyzed.Result: The levels of alanine aminotransferase, total bilirubin, preoperative AFP, HBV DNA high load, the amount of iodine oil and portal vein tumor thrombus were all statistically significant for the reactivation of HBV. There was no statistical significance in the reactivation of HBV by polymer microspheres and microsphere.Conclusions: HBV related hepatocellular carcinoma after transarterial chemoembolization(TACE) can lead to the reactivation of hepatitis B virus, especially of preoperative AFP, HBV DNA high load in amount of lipiodol larger occurrence of HBV reactivation. Therefore, we should be positive for jaundice, liver protection, antiviral treatment before TACE to prevent the reactivation of HBV on the prognosis of patients with liver damage effect.