The Association Between The Expression Of VE-cadherin And Mesentery Microcirculation Blood Flow Of Sepsis CASP Rats

objectives:To monitor the association between the expression of ve-cadherin and mesentery microcirculation blood flow of sepsis CASP rats.Methods:Based on the standard criteria,we established sepsis CASP rats,and the rats were divided into several groups according to the gauge of the vein detained needle in the ascending colon.The groups consisted of Sepsis A group22G(0.9*25mm,33ml/min),sepis B group20G(1.1*32mm,54ml/min),sepsis C group18G(1.3*32mm 80ml/min),sepsis D group 14G(2.0*45mm 270ml/min),in addition we established the control group.Real-time observation was performed by microscope on the 6h’s blood velcocity of each sepsis CASP rats group.Then we applied the immunohistochemistry to quantitatively analyze the expression of ve-cadherin of each group.Results: The blood velcocity of the mesentery microcirculation in control group was 583.21±52.39um/s,it was higher compared with the sepsis D group(213.30±52.39um/s)(p < 0.05),the blood velocity in sepsis A group was482.71±58.62um/s,higher compared with the sepsis D group(p<0.05).The score of the immunohistochemistry quantitative analysis of mesentery ve-cadherin in control group was 11.17±0.34,higher compared with the sepsis D group(5.43±0.43)(P<0.01).The score of sepsis A group was 10.07±0.30,higher compared with the sepsis D group(P<0.05).Conclusion:The expression of ve-cadherin of sepsis CASP rats had positive correlation with the blood velocity of the mesentery microcirculation of sepsis CASP rats.