| Purpose:The aim of the study was to investigate the brain structure volumes alterations in born and raised high altitude(HA)(> 3000M) normal adult by using voxel-based morphometry method(VBM).Materials and methods: Two groups of adults participated in the study, including an HA group [8 males and 8 females, meanage=21.81±2.07years] and an age- and education-matched SL group [7 males and 13 females,mean age=21.85±1.90years]. 3D-T1 structural images of All subjects who were underwent the whole brain scan were acquired.Then we used the VBM method to compared the whole brain GM and WM images differences between HA group and SL group.Results:HA acclimatization(vs. SL) showed increased gray matter volume in the left posterior cingulate, the left superior temporal gyrus,decreased GM volumes was found in the right insular lobe in highland group and we also found increased WM volumes in left thalamus,the right superior frontal gyrus,the lentiform nucleus,the left occipital lobe.Summarize: The VBM method was applied to the analysis of the magnetic resonance structural images and it could objectively display the volume changes of specific brain areas in HA group and could get us a comprehensive evaluation of the impact of altitude hypoxia on brain structure. |
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