Analysis Of Clinicopathological Characteristics And Prognosis Factors Of Gastric Cancer In Young Patients

Objective:Comparative and analysis clinicopathological characteristics, and to investigate prognosis risk factors of gastric cancer in young patients.Methods:Clinicopathological data of 103 gastric cancer in young patients(YGC,44 years of age and less) who underwent surgery, endoscopic and pathology diagnosis in the affiliated Jincheng Coal General Hospital of Shanxi Medical University from January 2010 to December 2014 were analyzed retrospectively. A total of 315 gastric cancer in older patients(OGC,60 years of age and more) during the same period patients were selected and compared and analysis to the young gastric cancer patients, to investigate prognosis risk factors of gastric cancer in young patients.Results:The male to female ratios was 1:1.5 and the percentage of female patients was predominant in the 103 YGC patients, and there was statistically significant different(P<0.001).As compared with the OGC patients, poorly differentiated adenocarcinoma and ring cell carcinoma were predominant pathological type in YGC(P<0.001).The first clinical symptoms were upper abdominal pain and hemorrhagic anemia in most of the YGC group. Gastric antruma was most common in the occurrence site of the tumor of the YGC group. The incidence of the Borrmann â…¢ type and â…£ type in YGC patients was statistically higher than of the OGC group(P<0.05).With regard to histological type, the most frequency type in the YGC group was diffuse adenocarcinoma(83%),which was statistically significant difference(P<0.001).Nothing can be compared with T3 stage and T4 stage of the depth of invasion, and clinical stage were â…¢ stage and â…£ stage in most of the YGC group(P<0.001).Patients with a family history of cancer in YGC were higherthan OGC, which was statistically different(P<0.05).There were no statistical significant difference in tumor diameter size, HP infection rate, level of albumin, level of serum CEA,vascular cancer embolus and incisal edge between the two groups(all P?0.05).On univariate and multivariate analysis showed that the depth of invasion, lymph node metastasis, degree of differentiation, clinical stage and surgical methods were the independent risk factors associated with the prognosis of YGC(all P<0.05).Conclusions:The incidence of YGC patients has increased obviously, which it accounts for 13.4%of the total number of gastric cancer. The YGC patients are usually female, obviously hereditary tendency, and tumor most locate at gastric antruma. The first clinical symptoms are lacking in specific, but upper abdominal pain and hemorrhagic anemia in most of the YGC patients. As compared with the OGC patients, poorly differentiated adenocarcinoma and ring cell carcinoma were predominant pathological type in YGC. â…¢ stage and â…£ stage was most common of clinical stage in young gastric cancer patients. The YGC patients are usually late diagnosis, highly malignant, early metastasis and poorly prognosis. The depth of invasion, lymph node metastasis, degree of differentiation, clinical stage and surgical methods were the independent risk factors associated with the prognosis of YGC.