To Discuss The Influence Of Jiechangning On Intestinal Barrier Function And Microecology Of Ulcerative Colitis Patients

Object: To Discuss the Influences of Chinese medicine Jiechangning on Intestinal Mucosal Barrier Function and Microecology of Ulcerative Colitis Patients.Method: 69 cases of UC patients in mild-to-moderate period were chosen and randomly divided into Jiechangning group、hormone group and control group, the latter two groups were as the experimental control group. 20 healthy subjects were selected as healthy control group. The Jiechangning group and hormone group were treated with retention enema combined with Mesalazine. The control group was only treated with oral Mesalazine. The treatment course of both groups was 30 days. The change of remission clinical symptoms、intestinal barrier functions and 10 kinds of intestinal flora in patients before and after treatment they were analyzed.Results:1、Before treatment the patients in all groups with different degrees of abdominal pain、diarrhea and mucopurulent bloody stool.While after the treatment the clinical symptoms of all patients had improved significantly(P<0.05).2、Before treatment lactulose/mannitol(L/M) ratio of all groups were higher than the healthy group(P<0.05), while after treatment there was no statistical significance compared with the healthy group(P>0.05).3、In the control group,Before treatment the yeast was higher than the healthy group, and the bacteria, Staphylococcus, Staphylococcus, Staphylococcus, bacillus, Lactobacillus, Lactobacillus and lactobacillus were all lower than those in the healthy group(P<0.05). while after treatment the number of microzyme and lactobacillaceae restored to balance, but bifidobacterium and other 7 kinds of bacteria species were still lower than that of the healthy group(P<0.05).4、In the Jiechangning group, Before treatment, the yeast and Clostridium were higher than the healthy group, and the bacteria, Staphylococcus, Staphylococcus, bacillus, Lactobacillus, Lactobacillus and lactobacillus were all lower than those in the healthy group(P<0.05).while after treatment the number of the microzyme、peptococcus、 clostridium、Bifidobacterium and lactobacillus was go back to normal level(P>0.05).5、In hormone group before the treatment, microzyme and clostridium were higher than the healthy group,staphylococcus, bifidobacterium, Lactobacillus and bacteroid all were lower than the healthy group(P<0.05);after the treatment the Lactobacillus and staphylococcus had no difference with the healthy group(P>0.05),enterobacteria、microzyme and clostridium all were higher than the healthy group,but the bifidobacterium and bacteroid were still lower(P<0.05).6、After treatment the number of bacteria in the Jiechangning group and control group was significantly higher than before(P<0.05), but compared with the control group, the Jiechangning group was more obvious(P<0.05),while after the treatment the number of the hormone group was even lower than before.Conclusion:While Jiechangning group、hormone group and control group were reducing clinically ease in mild-to-moderate period, at the same time they improved the permeability of intestinal mucosa. But in the recovery of intestinal flora balance and promoting proliferation of probiotics, Jiechangning group compared with the other two groups had a significant advantage.