Highly Efficient Synthesis Of 2-methyl-4-aryl-1H-inden-1-one And 2-methyl-7-aryl-1H-indene Via A Ligandless Palladium Catalysed Suzuki-coupling

Polyolefin materials are widely used in plastic industry because of corrosion resistance, good processability, and recyclability. To prepare novel polymer with expected properties, researchers kept designing high efficient catalytic systems for precisely control the molecular weight, molecular weight distribution and micro structure of polymer chains. Among series of homogenious olefin polymerization catalysts, metallocenes catalysts, especially 1-alkyl-7-aryl-1H-indene derived Zirconocenes attract continous attention for diversity structural modifications methods, excellent activities and selectivities.We focused on developing a high efficient ligandless Suzuki-Miyaura coupling process for preparing 2-methyl-4-aryl-1H-indan-1-ones, which are the key intermediates for the sythesis of 2-methyl-7-aryl-1H-indenes and metallocenes. The coupling reactions were carefully optimized and most of the reactions could proceed smoothly with 0.005% of Pd(OAc)2 as the catalyst.Different substituted 2-methyl-7-aryl-1H-indene were prepared in excellent yield following a reported reduction-dehydration procedure.