The Construction Of Continuous Flow Microreactor And Its Application In The Synthesis Of 2-imidazolines

Continuous flow micro-reactor was a new developed in the last two decades. Due to its small diameter, heat and mass transfer has a great advantage in terms to the conventional reactors. Therefore, the reactions in continuous flow micro-reactor often can get better results. But the continuous flow micro-reactor also have their limitations. Many continuous flow micro-reactors' operation is complex, and some reactor is limited to one or several reactions. This paper aims to build a continuous flow microreactor with simple operation, and can be applied to most organic synthesis reaction.First, we constructed a continuous flow microreactor with high-pressure preparative pump, tetrafluoroethylene tube, rooney lock syringe, heating mantle, and damping valve. We applied the reaction of synthesis of imidazoline with benzonitrile and ethylenediamine to improve this continuous flow microreactor. We replaced luer lock syringe by using a piston-type injector to solve the reactor pressure resistance. So the reaction can be made in high temperature, high pressure conditions. We used Inert fillers to replace dampling valve to avoid congestion.Next we changed the reaction time, temperature, catalyst concentration, reactant concentration in microreactor to explore the optimum conditions for synthesis of imidazolines. After that, we studied other nitrile compounds and ethylenediamine in a continuous flow reaction in the microreactor. We also explored the detection of such reaction conditions and purification methods. We contrasted the reaction to reaction in sealed tube controls. The results showed that most of the nitrile compounds can react with ethylenediaminef continuous flow smoothly in continuous flow micro-reactor.