Kinetic And Mechanistic Characterization Of Reduction Of Two Important Metal Complexes By Amino Acids

This thesis includes two research parts:（1） kinetics and mechanism for reduction of trans-[Pt（NH₃）₂Cl₄] in a wide pH range by two thiol-containing amino acids in human plasma L-cysteine and DL-homocysteine. The Pt（IV） complex is an anticancer active compplex.（2） A kinetic study of oxidation of L-asparagine by bis（hydrogenperiodato）argentate（III） complex anion([Ag（HIO₆）₂]^5–) in alkaline media.L-Asparagine has been used as a food additive. UV-vis and stopped-flow spectrometers were employed to follow the reaction kinetics, while high-resolution spectrometer was utilized to identify the oxidation products. Rate laws were established through a large number of kinetic measurements. Based on the rate laws and kinetic observations, reaction mechanisms were proposed and subsequently the rate expressions were derived. The rate constants for the rate-determining steps were evaluated. Biomedical and biological relevance is discussed in related with the present results.