Investigation On Self-powered Nanocomposites For Non-invasive External Power Supply Electrical Stimulation

Electrical stimulation plays a lead role in biology and medical treatment,such as neurite outgrowth,regulate differentiation and cerebral cortex.However,its power supply is still a challenge for non-invasive treatment.The application of electrical stimulation in the biological needs external power source as a power supply device.External power source for the application of electrical stimulation has brought a lot of inconvenience.We demonstrated a facile self-powered composite nanofibers(CNFs)to realize electrical stimulation based on Faraday’s law of electromagnetic induction to the non-invasive treatment and an external rotating magnetic field is applied.Based on it,we developed an electronic generating system.The self-powered CNFs consisting of multilayer modified MWNTs(m-MWNTs)coated Fe3O4/PCL fiber.The magnetic nanoparticles loaded in the electro spinning nanofibers can both strengthen the magnetic flux density effectively and then enhance conductivity properties of nanocomposites for the increase of the electric output.The corresponding short-circuit current density can reach up to 191.1 A/m2 under external magnetic field.Furthermore,this CNFs was employed to replace a frog’s sciatic nerve and effectively to realize the functional electrical stimulation.Influence of m-MWNTs,magnetic fluxes and the layers of the nanocomposites has been studied.The possible mechanism of the electric generation are also analyzed by COMSOL software.Furthermore,this CNFs was employed to replace a fiog’s sciatic nerve and effectively to realize the functional electrical stimulation.Evidently,this self-powered CNFs not only play a role as power source,but also can replace an injured nerve for non-invasive external power supply treatment under an external rotating magnetic field.The biological properties of the m-MWNTs coated Fe3O4/PCL fiber mats were investigated by cytotoxicity and cell biocompatibility.At the same time,tissue integration ability of the m-MWNTs coated Fe3O4/PCL fiber mats nanocomosites are also test by the muscle implantation.