Studies On The Interactions Between Polyphenols Drugs And Cyclodextrin Derivatives And Its Solution Thermodynamics

Disease endangers the human health and affects people’s quality of life.Treating diseases has spent lots of social wealth.Revealing the pharmacodynamic mechanism and improving the efficacy of the drug have become a hot research topic.Phenolic compounds are ubiquitous in some plants,which were reported having anti-cancer,anti-inflammatory,and treatment of obesity activities.The inclusion technology of cyclodextrin derivatives can obviously improve the solubility,stability and bioavailability of the drugs.The researches on the thermodynamic properties of solution can illuminate the interaction mechanism among solute and solvent molecules.The studys on the interactions between cyclodextrin derivatives and drug molecules and the thermodynamic properties of drug molecules in simulated body fluid,could reveal the mechanism of drug effect in vivo and provide theoretical basis to for the development of more effective drugs and new drug.On the basis of literature investigation and the device of laboratory,we studied the interactions of bisdemethoxycurcumin with cyclodextrin derivatives at different pH and temperatures by the phase-solubility method.Study on the thermodynamic properties of drugs in simulated body fluid using calorimetry,density methods can explore the mechanism of the interaction between solute and solvent molecules.As a part of the project supported by National Natural Science Foundation(NO.21473085),the present work mainly composed of four parts:In the first part: The host-guest interactions of bisdemethoxycurcumin with sulfobutyl ether-β-cyclodextrin(SBE-βCD),methylated-β-cyclodextrin(M-βCD)at different p H and temperatures were investigated using the phase-solubility method.The interaction mechanism between drug and β-CD derivatives molecules was studied on the basis of the thermodynamic parameters.In the second part: The enthalpies of dilution,volumetric properties of protocatechualdehyde in sodium and potassium phosphate buffer solution at different pH were researched.The effect of pH on the thermodynamic parameters was analyzed.The discrepancy of enthalpies of dilution and volumetric properties between sodium and potassium phosphate buffer solution were interpreted from their different ionic structure.In the third part: The enthalpies of dilution,volumetric properties of protocatechualdehyde and p-hydroxybenzaldehyde in the aqueous sodium chloride solutions were researched.The interaction mechanism among solute and solvent molecules in salt solutions were clarified in terms of(solute+solute)and(solute + solvent)interactions.In the fourth part: The enthalpies of dilution,volumetric properties of protocatechualdehyde and p-hydroxybenzaldehyde in the aqueous potassium chloride solutions were researched.The influence of the different molecular structures of protocatechualdehyde and p-hydroxybenzaldehyde on their thermodynamic properties was discussed in terms of the(solute + solute)and(solute + solvent)interactions.The discrepancy of thermodynamic properties between sodium and potassium chloride solution were interpreted from their different ionic structure.