The Study Of Photoinduced CO Releasing Molecules By Flavonol And Its Derivatives

The study found that the production of a small amount of carbon monoxide(CO)is beneficial to the rehabilitation of the disease,so the development of CO treatment reagents has aroused strong interest.In order to avoid the inherent limitations of metal carbonyl complexes as photoCORMs(e.g.the wavelength of the induced light they needed is short(<365 nm)and the photoinduced CO release reaction of them is often reversible).In this paper,we use flavonol,4-Methoxyflavonol and 4-Methoxyflavothione as photoinduced CO releasing units,transition metals and auxiliary chelate ligands as structural adjustment factors to develope a new system of photoCORMs which can release CO molecules if induced by visible light.A series of works are summarized as follows:1.Three photoinduced CO releasing units flavonol,4-Methoxyflavonol,4-Methoxyflavothione and five auxiliary chelate ligands tris(2-methylpyridyl)amine and its derivatives have been designed,synthesized and characterized.2.With ligands bis(6-methyl-2-pyridyl)methyl)-(2-pyridylmethyl)amine(6-Me2TPA)and 4-Methoxyflavonol(4-MeOFLH),and a series of photoCORMs([(6-Me2TPA)M(4-MeOFLH)]ClO4(M = Mn(Ⅱ),Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ))are designed,synthesized and characterized.Their structures,spectroscopic and quantify of CO have been systematically investigated and found that the metal zinc complex was able to release equimolar CO at an appropriate rate.3.With metal zinc(Ⅱ)ions,auxiliary chelating ligands and the photoinduced CO releasing unit of flavonol,4-Methoxyflavonol,4-Methoxyflavothione,a series of photoCORMs are designed,synthesized and characterized.Their structures and quantify of CO have been systematically investigated.4.The reaction mechanism of light-induced carbon monoxide release reaction of each complex was evaluated by the choice of solvent,irradiation wavelength,product identification and O2 dependence.5.The stability of the complexes[(L)Zn(FLH)]ClO4,[(L)Zn(4-MeOFLH)]ClO4,[(L)Zn(4-MeOFLTH)]C104(L = TPA,6-MeTPA,6-Me2TPA,BPQA,BQPA)are investigated by UV-vis.