Palladium-Catalyzed Regioselective C8-H Amination Of 1-Naphthylamine Derivatives With Aliphatic Amine

What is reported in this thesis is a kind of method to synthesize 1,8-diaminonaphthalene compounds which is assisted by picolinamide groups and palladium catalytic direct amination reaction,meanwhile,with 1-Naphthylamine,its derivatives and amine compound as substrates.Under the help of catalytic systems for Pd(OAc)2,and oxidition for N-Hydroxyphthalimide,the reaction not only has simple conditions,but also has good regioselectivity.Reaction with electron-withdrawing,electron-donating and electrical neutral substituent of 1-Naphthylamine compounds,and secondary amine compounds,they all obtained medium to high production rate.The reaction has remarkable regioselectivity,it realized the reaction of 1-Naphthylamine and C8-H direct amination by regulate conditions.The completion of the reaction,simplified the synthesis of 1,8-diaminonaphthalene derivatives steps,and synthesized a series of new sepcies.The scope of reaction substrate is wide,it is the first example of 1-Naphthylamine C8-H direct amination reaction.