Synthesis And Characterization Of Block Copolymer Poly(γ-benzyl L-glutamate) And Polyphosphate

Amphiphilic copolymers,which could self-assemble into aggregates such as micelles and vesicles,are capable for applications in drug delivery.Polyphosphoesters,exhibiting both distinguished biocompatibility and structural versatility,are potential for biomedical applications.A series of biodegradable amphiphilic copolymers of polyphosphoester were synthesized by ring-opening polymerization of ethyl ethylene phosphate(EEP).The structures of the block copolymers were confirmed by FT-IR,1H-NMR and GPC analysis.Fluorescence measurements were applied to determine the critical micelle concentration(CMC)of the copolymer micelle solutions.A series of amphiphilic biodegradable poly(γ-benzyl L-glutamate)/poly(ethyl ethylene phosphate)(PBLG-b-PEEP)block copolymers were synthesized via ring opening polymerization of N-carboxy-y-benzyl L-glutamate using amion terminated poly(ethyl ethylene phosphate)and stannous octoate co-initiation system.FT-IR.1H NMR and GPC were used to demonstrate the structure and their compositions which would be adjusted by alternation of the feeding ratio of initiator and monomer.The results showed that the target products were synthesized,and the molecular weight can be controled by changing the feed ratio of reactants.