Study On Electrochemical Biosensors Based On Transition Metal Sulfide/Functionalized Ordered Mesoporous Carbon Nanohybrids

Transition metal sulfide nanomaterials have excellent optical,electrical and catalytic properties. Ordered mesoporous carbon has a large specific surface area, excellent catalytic, adsorption and conductivity properties. Taking advantage the transition metal sulfides nanomaterials and functionalized ordered mesoporous carbon nanomaterials, the novel electrochemical biosensors based on transition metal sulfide/ordered mesoporous carbon was developed for the determination of dopamine and nitrite. The specific contents are as follows:1. MoS2 nanomaterial was synthesized by solvothermal reaction route, by grinding MoS2 with functionalized ordered mesoporous carbon(f-OMC) and ionic liquids (IL) to modify the nanohybrids to the surface of glassy carbon electrode. Then a novel electrochemical senor based on f-OMC-MoS2/IL/GCE for dopamine (DA) was constructed. The electrocatalytic performance of the sensor toward DA was investigated.Under the optimized conditions, the DA was detected by differential pulse voltammetry (DPV), and the results of recovery were satisfactory in human serum and Dopamine hydrochloride Injection.2. A new cobalt doped molybdenum disulfide (CoMoS2)nanomaterial was synthesized by using acetone as the solvent, using MoS2 and octacarbonyldicobalt as raw materials in the condition of constant temperature oil bath distillation. By grinding CoMoS2 with f-OMC and IL to modify the nanohybrids to the surface of glassy carbon electrode, then a novel electrochemical senor based on f-OMC-CoMoS2/IL/GCE for DA was constructed. The electrochemical behavior of dopamine on the surface of the modified electrode was studied.And also the sensing properties were discussed. The results showed that the catalytic activity of f-OMC-CoMoS2/IL/GCE was higher than that of f-OMC-MoS2/IL/GCE, and it could also be used for the detection of dopamine in the practical samples.3. A new type of nitrite electrochemical sensor was prepared by f-OMC-CoMoS2/IL/GCE. The electrocatalytic oxidation performance,mechanism of nitrite and the sensing properties of the sensor was investigated. The sensor has the advantages of wide detection range(1-6700 μmol·L-1), low detection limit (0.04 μmol·L-1), good reproducibility (RSD is 3.3%) and exhibits notable catalytic performance toward oxidation of nitrite.