Synthesis Of Phenylalanine

Phenylalanine is one of the eight major amino acids,which is essential,but can not be synthesized.It is Mainly used in the field of medicine,food additives and animal feed additives.In recent years,with the development and application of the amino acid class of anticancer drugs,nutritional supplements and new high-intensity sweetener aspartame extensive production and use,the demand of the phenylalanine are rapidly increasing.Therefore,to carry out the synthesis of phenylalanine is of great significance.In this thesis,We select and optimize the synthesis process of phenylalanine,and produce waste processing.Include the following findings following:1.By summarized and analyzed the literature,selected phenylalanine synthesis process:bromobenzene as the starting materials by addition,hydrolysis,aminolysis to generate DL-Phenylalanine.2.Selectd A catalyst in the reaction of phenyl magnesium bromide with acrylonitrile,discussed the impact of the copper catalyst on the product of the conversion rate.3.In order to improve the reaction yield,we optimization of process conditions to get the most favorable conditions.Following results were obtained:① Addition reaction of phenyl magnesium bromide with acrylonitrile:Phenyl magnesium bromide:acrylonitrile(molar ratio)= 1:1.5;reaction temperature:40℃;reaction time:3h.②Bromo styrene-acrylic nitrile hydrolysis reaction:Brominated styrene-acrylic nitrile(g):concentrated hydrochloric acid(mL)= 1:3;reaction temperature:reflux temperature;reaction time:4h.③Bromide phenylpropionate ammonolysis:Bromo styrene-acrylic acid(g):concentrated ammonia(mL)= 1:5;reaction pressure:3atm;reaction temperature:100℃;reaction time:48h.Above reaction conditions,we conducted the stability experiment,the reaction yield and content of stability,with an average yield of 68.5%,with an average content of 98.2%.4.Process to enlarge the research,design and process flow diagram,floor plan,the preparation of the technical operation,research and identified the intermediates and product quality control indicators and analytical methods.5.In order to avoid waste pollution,we conducted a study of the waste treatment programby neutralization,biochemical processing.PH value of the treated wastewater:7.49,chemical oxygen demand:121mL/L,and Ammonia content:12.9mg/L,reached the "Integrated Wastewater Discharge Standard(GB8978-1996)in three standard concentration limits.