| CuAAC provides an efficient route to construct 1,2,3-triazoles by combining two potential blocks under mild condition in a high regiospecific manner.1,2,3-Triazoles are important five-membered nitrogen heterocycles with high chemical stabilities.The molecules containing triazole nucleus are involved in various research areas including biological chemistry,pharmaceutical science,material science and organic synthesis.The Suzuki–Miyaura reactions provide an attractive and efficient route to construct Csp2-Csp2 bond for the synthesis of a variety of important chemicals or structural motif for their applications in pharmaceuticals and advanced materials.Recently,much effort has been focused on the surface modification of MNPs with appropriate capping agents to anchor the catalytic active species.The main advantage of a catalytic system based on MNPs is that the catalyst can be easily recovered from the reaction mixture simply by using an external magnet.The details are as follows:1.Metathesis strategy for the immobilization of copper?II?onto carboxymethylcellulose/Fe3O4 nanohybrid supports: the ensuring catalyst has been successfully applied in the CuAAC reaction of benzyl halides,sodium azide,and terminal alkynes to the synthesis of 1,2,3-triazoles.Furthermore,the CuII-CMC-Fe3O4 could be easily isolated and recovered by magnetic decantation and reused for five consecutive cycles without much loss in activity.2.The Pd nanoparticles?Pd NPs?embedded on magnetically retrievable carboxymethylcellulose/Fe3O4?Pd0@CMC/Fe3O4?organic/inorganic hybrid were prepared via the conventional simple process.This hybrid catalyst was very effective in the Suzuki-Miyaura reaction of a variety of aryl halides with arylboronic acid to afford excellent product yields.The catalyst showed good stability and could be easily recovered with an external magnetic field and reused for several times without a significant loss in its catalytic activity. |
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