| Utilizing fluorescent quenching or quenched-on to determine environmental metal ions or biomolecules is a real-time,convenient and cost effective method.Colorimetric paper sensor based on fluorescent nanomaterials for large color varying range,high selective and sensitive heavy metal ions detection attracted numerous researches and reports.(1)In this paper,we report a ratiometric fluorescent probe based paper sensor regulated the optimum proportion of gold nanoclusters stabilized by bovine serum albumin and fluorescent graphene oxide to achieve the maximum consecutive color change for visual determination of blood glucose.The oxidation of glucose produced hydrogen peroxide,which quenched the red fluorescence emission of gold nanoclusters,and unveiled a consecutive color change from pink to blue with the corresponding dosage of glucose.This colorimetric paper sensor printed with the probe-ink exhibited a dosage-sensitive allochromatic capability for the blood glucose concentration of 4 mM-10 mM in human serum(normal:4.4 mM-6.6 mM).This paper sensor was not only utilized to determine glucose level according color change,but developed qualified fluorescent paper sensor for valuing glucose concentration of human serum accurately to judge whether it is normal or not simply.Therefore,the fluorescent sensor paper could provide a simple and convenient way in predicting diseases relative to abnormal glucose level.(2)Silicon quantum dots or Silicon Nanoparticles possess high fluorescent intensity and quantum yields(～12%)compared with carbon dots,and it is good bio-compatible,nontoxic,and biodegradable and excreted readily.Silicon quantum dots synthesis by a one pot hydrothermal method with Amine propyl trimethoxysilane emitted bright blue fluorescence.The emission intensity was decreasing while introducing H+ due to formation of hydrogen bond and F-can recover part of its fluorescence thank to high affinity between F-and H+.This synthetic method is extremely simple,repeatable and low cost. |
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