Studies On Free-radical Alkylation Of Heteroaromatics Using Alkene As The Alkyl Radical Precursor

This thesis demonstrated a novel strategy for alkylation of heteroarenes,which used alkenes as the radical precursors via a single electron transfer（SET）process.It includes three parts as following.Part one depicted the research development of alkylation of heteroarenes.Firstly,we summarized Minisci reaction,which explains its significance and procession in synthetic chemistry as the method of heterocyclic alkylation.Secondly,the studies on free radical precursors were described,which also introduced the advances in radical alkylation of heteroarenes,such as carboxylic acid,alkyl boronic acids etc.;Finally,the coupling reactions between alkenes and heteroarenes via transition-metal catalysis were summarized here.Part two demonstrated a free-radical-mediated intermolecular hydroheteroarylation of simple alkenes was developed.Through simply mixing heteroarene,alkene,Fe（III）,and NaBH₄ at 0℃together,a wide range of alkylated heteroarenes could be afforded in moderate to excellent yields within one hour.Part three summarized this new strategy and the expectations of its development and implication were also described.