Correlation Research Opn Micro-inflammatory State And Thyroid Function Of Chronic Kidney Disease (CKD-5Period) Patients Abstract

Objectives:Probe the correlation between micro-inflammatory state and thyroid functionof chronic kidney disease(CKD-5period) patients.Through this experiment we determinedCKD-5patients’ thyroxine levels and studied their correlation with related indicators ofbody’s micro-inflammatory,assessed the uremia micro-inflammatory’s impact on thyroidfunction.Methods:From January2013to January2014,60CKD-5patients who were treated inQinghai university affiliated hospital nephrology department were chosen as theexperimental group,they were divided into dialysis group and non-dialysis group,30casesin each group.The selected candidates met the definition of CKD and staging criteriaaccording to U.S K/DOQI,2002.The dialysis time of hemodialysis patients ranged from6months to2years,all the selected patients had no pulmonary infection history,primarythyroid disease or malignancy history recently,their general situations wereacceptable.Then selected30healthy people from Qinghai university affiliated hospitalmedical center whose age and sex matched with the experimental group as healthy controlgroup,they had no cardiopulmonary disease and their liver and kidney function wasnormal.Each group had no statistically significant at age and gender composition,theobjects were comparable.Applied SPSS17.0software for statistical analysis,measurementdata were expressed asx±S,data between groups were analyzed using single-factoranalysis of variance,correlation analysis was analyzed using linear correlationanalysis,inspection standard was a=0.05,considered P<0.05as statistically significant.Results:1.The serum thyroid hormone,ALB and CRP were different comparedexperimental group and control group(P<0.05),the differences were statisticallysignificant.This result suggested that serum thyroid hormone levels and serum ALB levelsin experimental group were lower than control group,serum CRP levels were higher thancontrol group,the differences was statistically significant between dialysis group andnon-dialysis group.2.Correlation analysis of experimental groups’ relevantindicators:serum thyroid hormone had a positively correlation(P<0.05) with ALB,and anegatively correlation with serum CRP(P<0.05). Conclusions：1.In end stage renal disease patients,thyroid hormone levels,serum ALBlevel are significantly lower relative to healthy people,the serum CRP level is significantlyhigher relative to healthy people.Patients’ thyroid hormone levels and serum ALB levelafter dialysis elevate significantly relative to non-dialysis,but serum CRP level reducesignificantly compare to non-dialysis patients.This may suggest the presence of thyroidfunction changes and micro-inflammatory symptom caused by non-thyroid disease,and thecombination of low albumin,then the symptoms mentioned above are relievedsignificantly after the patients receiving dialysis treatment.Therefore, the study provides aclinical reference for us to take early hemodialysis intervention measure to reduce theoccurrence of these complications,and then reduce relevant complications brought bybody thyroid function’s changing,when chronic kidney disease develops to the end stage.2.In end stage renal disease patients,serum thyroid hormone levels and serum CRP arenegatively correlated,serum thyroid hormone levels and serum ALB are positivelycorrelated,which prompts there is a certain relationship between patients’ thyroid functionchanges and micro-inflammatory state’s severity.Thus,our study can provide the basis fordialysis population to adopt clinical interventions actively,for example,apply highbiocompatibility dialysis membrane to reduce the occurrence of micro-inflammatory stateand supplement albumin so that we can prevent the aggravation of hypothyroidism causedby thyroid function changes.