The Correlative Study Between Coronary Teriography,Coagulation Indexes And TCM Syndrome Differentiation-type In Unstable Angina Pectoris

Objective:Via collecting the basic information of clinical cases, four diagnostic methods of TCM, the results of coronary angiography, activated partial thromboplastin time (APTT) and fibrinogen(FIB), this study analyze the relationships among the TCM-Syndrome differentiation type of Unstable Angina Pectoris, the coronary angiography and APTT and FIB, and offer some criteria for TCM-Syndrome Differentiation type.Method:These clinical cases are all from120inpatients in the Cardiology Department of Jiangsu Provincial Hospital of Traditional between March,2013and March,2014, who are diagnosed explicitly Unstable Angina Pectoris and given Percutaneous coronary intervention(PCI)。1. By collecting the basic information of every case, syndrome of TCM and conveying clinical dialectical analysis on all the patients.2. By interpreting and analyze the results of coronary angiography of, the patients, and making the classification of the number of coronary lesion and degree of coronary artery stenosis.3. By collecting the index of APTT and FIB which were the results of the morning fasting venous blood.4. By using SPSS Version19.0to compute and analysis the data obtained from step1to3.Result:1. APTT levels is lower than the control group while FIB is high than the control group in patients with unstable angina。There is a significant difference between the UAP group and the control group(P<0.01).2. APTT, FIB of every TCM syndrome type has a significant difference(P<0.01).①In every syndrome, the order of APTT level from low to high is heart blood stasis syndrome, Qi deficiency and blood stasis syndrome, Qi-Yin deficiency syndrome, phlegm accumulated syndrome, Yang Qi deficiency syndrome. There is a significant difference among heart blood stasis syndrome and Qi-Yin deficiency syndrome, phlegm accumulated syndrome, Yang Qi deficiency syndrome(P<0.01), the difference between Qi deficiency and blood stasis syndrome and Yang Qi deficiency syndrome is statistically significant (P<0.05), There is no statistical difference among Qi-Yin deficiency syndrome, phlegm accumulated syndrome, Yang Qi deficiency syndrome (P>0.05).②In every syndrome, the order of FIB level from high to low is heart blood stasis syndrome, Qi deficiency and blood stasis syndrome, Qi-Yin deficiency syndrome, phlegm accumulated syndrome, Yang Qi deficiency syndrome. There is a significant difference between heart blood stasis syndrome and the other four syndromes(P<0.01), the difference among Qi deficiency and blood stasis syndrome and phlegm accumulated syndrome, Yang Qi deficiency syndrome is statistically significant (P<0.05). There is no statistical difference among Qi-Yin deficiency syndrome, phlegm accumulated syndrome, Yang Qi deficiency syndrome (P>0.05).3. There is no statistically significant difference among the average number of coronary artery stenosis in every UAP TCM syndrome type (P>0.05). APTT of Single, double, multi coronary lesion is gradually decreasing while FIB level gradually increased. But APTT of the single, double coronary lesion has no significant difference (P>0.05).4. The Gensini scores of coronary artery lesion in differemt TCM-SDT of UAP have very marked difference(P<0.05). Theorder of Gensini score of differernt TCM-SDT in UAP ranged: heart blood stasis syndrome>Qi deficiency and blood stasis syndrome> Qi-Yin deficiency syndrome> Yang Qi deficiency syndrome>phlegm accumulated syndrome. Contents APTT、 FIB in different Gensini score of coronary artery lesion have very marked difference (P<0.01). Content of APTT from high to low n FIB from high to low with Gensini score of three groups is group of<20score, group of20-40score, group of>40score.Conclusion:1. There is a closely relationship between APTT, FIB and UAP TCM syndrome type, especially in heart blood stasis syndrome and Qi deficiency and blood stasis syndrome.2. There’s a significant difference in the relationship between APTT、FIB and the severity of coronary artery lesions, the number of coronary artery lesions. APTT, FIB can be used as a measurement of coronary artery disease index to evaluate the severity of UAP.3. What to be done in describing the relationship between coronary angiography and TCM syndrome of UAP need estimate synthetically branch, narrow degree, character and form of coronary artery lesion.4. The relationship that is analyzed among APTT,FIB, Coronary Arteriography and TCM-SDT of UAP provide objective evidence and new thoughts and methods for clinical diagnosis and treatment of UAP.