| Objectives:1. to explore with 3 D printing porous coating titanium implants and bone induction of calcium phosphate bioceramics bone(particles) feasibility of combined treatment Osteonecrosis of the femoral head in canine2. Explore the 3 d printing porous coating titanium rods and bone induction of calcium phosphate bioceramics bone(rod) combined with pulp core decompression can enhance the ability of femoral head collapse resistance,delay the progression or effective treatment of femoral head necrosis.3. Comparison of 3 D printing porous coating titanium rods and bone induction of calcium phosphate bioceramics bone(particles), 3 D printing porous coating on titanium rods, bone induction of calcium phosphate bioceramics bone(bar)and not conservative surgery efficacy for the treatment of femoral head necrosis.Methods:Will only 32 healthy adult beagle randomly divided into 4 groups, line 6 weeks postoperatively, liquid nitrogen making mould for A, B, C, D four groups,group A, line pulp core decompression combined with 3 D printing porous coating titanium rods and bone induction of calcium phosphate bioceramics bone(particles) implantation. Group B line pulp core decompression combined with porous coated titanium rod implantation, 3 D printing line group C bone induction of calcium phosphate bioceramics bone(bar). Group D for the control group, pure pulp core decompression. Different surgical treatment of group A and group B, group C, group D beagle in postoperative 6 w, 12 w line imaging examination after death, histologic sampling for the line, and gross observation,histological and biomechanical examination and imaging examination.Histologic cell count and HE biopsy, cell count by using two independent sample T test. Biomechanical pressure as a result, using two-factor variance analysis and comparison of 6 w and 12 w and the different ways of operation whether compressive strength difference was statistically significant, line Dunnett test are compared, and two(P < 0.05 for statistical significance.Results:Gross observation, radiographic, histologic and biomechanical observation:group A 6 w and 12 w beagle femoral head morphology neat, density uniformity, color normal cartilage, smooth surface, no distortion, transparent,femoral head did not see obvious subsidence, significantly enhance the compressive capacity of femoral head. 3 d printing porous coating titanium rods and bone induction of biological ceramic bone combined with surrounding bone tissue, loose titanium rods did not see out. Contains calcium phosphate bioceramics induction of bone formation and new bone cells have a lot of new bone cells arranged more neatly. Group B 6 w and 12 w shape and structure of femoral head owe neat, color normal cartilage, owe smooth surface, no obvious deformation, transparent, not seen obvious subsidence, femoral head pressure resistance ability of the femoral head. 3 d printing porous coating titanium rod combined with surrounding bone tissue, loose porous titanium rods did not see out. No obvious new bone formation. Group C 6 w and 12 w shape and structure of femoral head owe neat, color slants dark, cartilage surface deformation of mild, transparency is poor, femoral head appears mild collapse.Femoral head compressive capacity increased, materials combined with the surrounding bone tissue is poorer, visible formation of new bone cells obviously,but the new bone cells arranged chaos. Group D as control group 6 w and 12 w shape and structure of femoral head not neat, color slants dark, cartilage surface deformation, transparency is poor, the femoral head in collapse, subchondral bone cystic change and capsule obviously surrounding tissue hardening, core decompression after not implanted material defect in the area covered by a large number of connective tissue, and connective tissue around a small bone cells, and cell arrangement is irregular.To sum up, group A and group B was enhanced ability to resist the pressure, but group B did not see A lot of new bone cells. Group A, group C material around the bone marrow cells contain A large number of bone formation, although there are A large number of new bone cells, group C without the sickly mechanical support new bone cells.Conclusion:1. 3 d printing porous coating titanium rods and bone induction of calcium phosphate bioceramics bone(particles), combination therapy is feasible for early femoral head necrosis.2. 3 D printing porous coating titanium rods significantly enhance compressive capacity of femoral head.3. Bone induction of calcium phosphate bioceramics bone can induce new bone regeneration in bone defect area. |
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