Correlation Of IL-8 And IL-6 In Prostatic Fluid With Serum Prostate-specific Antigen Level In Patients With Benign Prostatic Hyperplasia Complicated By Prostatitis

BackgroundCurrently,most studies on the correlation analysis between abnormally elevated serum PSA and prostatitis are confined to the level of inflammation histopathology.In other words,according to the pathological features of prostate tissue inflammation,analyze the relationship between prostatitis and serum PSA.However,in order to analyze the characteristics of prostate tissue inflammation,can only take some invasive means to get prostate tissue samples,usually brings a lot of damage.For this reason it is restricted to the value of clinical applications.And more and more evidence that prostatitis caused by abnormally elevated serum PSA,after the anti-inflammatory treatment can be reduced.Meanwhile,some studies show that prostatic fluid IL-8,IL-6 can be considered as a more reliable marker of inflammation.Some studies on the correlation between prostate fluid or serum interleukin levels and serum PSA levels have not yet been determined.ObjectiveTo investigate the correlation of the levels of interleukin-8(IL-8)and interleukin-6(IL-6)in the prostatic fluid with serum levels of serum prostate-specific antigen(PSA)in patients with benign prostatic hyperplasia(BPH)complicated by prostatitis.MethodsA series of 211 patients undergoing surgery of BPH were divided into BPH group(n=75)and BPH with prostatitis group(n=136)according to the white blood cell count in the prostatic fluid.The clinical and laboratory findings(Including age,body mass index,blood pressure,blood sugar,blood lipids,IPSS,prostate volume,PSA,f-PSA,PSA-Ratio,PSAD,IL-8,IL-6)were compared between the two groups,and stepwise regression analysis was used to assess the association of IL-8 and IL-6 with serum PSA level.ResultsNo significant differences were found in age,BMI,blood pressure,blood glucose,blood lipids,IPSS score,PSA-Ratio,or prostate volume between the two groups(P>0.05).The patients with prostatitis had significantly increased serum PSA and prostate fluid IL-8and IL-6 levels compared with those without prostatitis(P<0.001).Multiple linear regression analysis showed that IL-8 and IL-6 levels and white blood cell count in the prostatic fluid were all positively correlated with serum PSA level.ConclusionsProstatitis is an important risk factor for elevated serum PSA level in patients with BPH,and both IL-8 and IL-6 levels in the prostatic fluid can serve as reliable markers to predict abnormal serum PSA caused by prostatitis.