The Effects Of Mosapride On EGG Of Patient With Functional Dyspepsia

Object:To observe the effects of Mosapride on EGG of patient with functional dyspepsia;To investigate the clinical effects of mosapride in patients with FDMethod : Subjects were 105 patients with functional dyspepsia whom were choosen randomly from consecutive successive hospital inpatients of digestive system department observed,and HP was being tested on each patient with a 14C-UBT.Those 88 patients who was Hp-nagetive were divided into three groups randomly: Treatments of Omeprazole(40mg Bid)for 4 weeks were given to the first group’s patients.Treatments of mosepride tablet(5mg Tid)and Omeprazole(40mg Bid)for 4 weeks were given to the second group’s patients;Treatment of mosepride tablet(5mg Tid)and Omeprazole(40mg Bid)and Deanxit tablet(one tablet Qd)for 4 weeks were given to the patients of the third group.24 healthy volunteers were choosen as the matched group,marked the fourth group.Patients’ fasting and postprandial EGG which including PR、DF、DP、N%、B%and T%was recorded by EGG recorder measurements before and after the treamment in all first three groups.At the meantime,record the indexes all above of the fourth group’s patients.anxiety score points and depression score points calculated and compared before and after treatment in third group with SAS and SDS.Results:(1)Dominant frequency(DF),postprandial dominant power(DP)and power ratio(PR)were lower in all first three groups than the indexes of the fourth group before treatment,the differences were statistically significant,but the fasting dominant power(DP)were not statistically significant.Normal slow waves(N%)were lower in all first three groups than the indexes of the fourth group before treatment,the differences were statistically significant.(2)Fasting and postprandial Dominant frequency(DF)and power ratio(PR),postprandial dominant power(DP)after treatment were higher compared with these indexes before treatment in the first group.The differences were statistically significant.The differences of fasting dominant power(DP)were not statistically significant bettwin before and after treatment.The Normal slow waves(N%)after treatment were significantly higher than before treatment.(3)Fasting and postprandial Dominant frequency(DF)and power ratio(PR),postprandial dominant power(DP)after treatment were higher compared with these indexes before treatment in the second group.The differences were statistically significant.The differences of fasting dominant power(DP)were not statistically significant bettwin before and after treatment.The Normal slow waves(N%)after treatment were significantly higher than before treatment.(4)Fasting and postprandial Dominant frequency(DF)and power ratio(PR),postprandial dominant power(DP)after treatment were higher compared with these indexes before treatment in the third group.The differences were statistically significant.The differences of fasting dominant power(DP)were not statistically significant beetwin before and after treatment.The Normal slow waves(N%)after treatment were significantly higher than before treatment.(5)Compared with the first group,the Fasting and postprandial Dominant frequency(DF)and power ratio(PR),postprandial dominant power(DP)and the fasting Normal slow waves(N%)after treatment were higher in the second group,the differences were statistically significant.The fasting dominant power(DP)and the postprandial Normal slow waves(N%)compared with the first group were not statistically significant in the second group.(6)Compared with the first group,the Fasting and postprandial Dominant frequency(DF)and power ratio(PR),postprandial dominant power(DP)and the fasting Normal slow waves(N%)after treatment were higher in the third group,the differences were statistically significant.The fasting dominant power(DP)and the postprandial Normal slow waves(N%)compared with the first group were not statistically significant in the third group.(7)Compared with the second group,the Fasting and postprandial Dominant frequency(DF)and power ratio(PR)and dominant power(DP)and the Normal slow waves(N%)after treatment in the third group were all not statistically significant.(8)anxiety score points and depression score points after treatment in the third group were significantly lower compared with the points before treatment.Conclusions:(1)Gastric electrical rhythm disorder and descent gastrointestinal exists in patients with functional dyspepsia.(2)Omeprazole 、Mosapride combined with Omeprazole、Mosapride combined with Omeprazole and Deanxit can dramatically improve gastric electrical rhythm disorder and descent gastrointestinal in patients with functional dyspepsia.(3)Compared with Omeprazole,the drug combination group of Mosapride and Omeprazole and the drug combination group of Mosapride and Omeprazole and Deanxit are more effective in improving gastric electrical rhythm disorder and descent gastrointestinal in patients with functional dyspepsia,but difference beetwin the two groups is not magnificent.(4)Anxiety and depression are exist in patients with functional dyspepsia,the drug combination group of Mosapride and Omeprazole and Deanxit can improve the anxiety and.depression of patients with functional dyspepsia.