Clinical Manifestations And Imaging Analyses Of Moyamoya Disease

Objective:Moyamoya disease with low incidence,clinical manifestations is varied and lack of specificity,If not to raise awareness of the disease and do cerebrovascular check early will easily missed diagnosis and misdiagnosis,Do early detection,early treatment of the disease can effectively slow down the progress of the clinical symptoms of the disease,which can bring great benefit to the patients themselves,family and society.This resesrch through collecting the general situation,clinical and radiographic features to deepen our understanding of the disease.Methods:This paper collected 33 patients medical records,who were clear diagnosis of moyamoya disease during January 2000 to December 2015 in 2ad Affiliated Hospital of Dalian Medical University neurology and neurosurgery..Detail recording every patient,age,gender,clinical symptoms,signs and imaging results.Retrospectively analysis the general situation,clinical and radiographic feature.Using SPSS 19.0 software to statistical analysis,measurement data to mean + /-standard deviation(+ s);Rate compared by chi-square test,if P < 0.05,the difference has statistically significant.Results:General situation:33 patients with the youngest is 14 years old and the oldest is 72 years old,average age(41.85 + 14.25),the disease can happen all ages,but the middle-aged and young with the proportion of larger,higher onset age stage is 36 years old to 50 years old.Ischemic cerebrovascular disease and hemorrhagic cerebrovascular disease can happen in each age stage,but the onset of ischemic cerebrovascular disease age generally younger than cerebral hemorrhage.Women in patients is 21 cases,with male12 cases,the male to female ratio of 1:1.75.,1 patient is suspected of family genetic predisposition,the rest of the patients were not found to have family history of the disease.Clinical manifestations:There were 10 cases of ischemic cerebrovascular disease and 23 cases of hemorrhagic cerebrovascular disease of 33 cases,the ratio is 1:2.3,hemorrhagic cerebrovascular disease is significantly higher than the proportion of ischemic cerebrovascular disease,the difference was statistically significant(chi-square= 5.121,P < 0.05).Its clinical manifestation as pain decreased is 2 people,13 people hemiplegia,8 people aphasia,cognitive dysfunction(embodied in memory and mental symptoms)5 people,nonspecific symptoms(headache,dizziness,nausea and vomiting)21 people,consciousness disorder 5 people(1).Imaging results: this group of 33 patients all use MRI or CT brain scan.32 patients using DSA(Digital Subtraction Angiography)diagnosed,1 patient with crani ocerebral MRA diagnosis.10 is chemic cerebrovascular patients were diagnosed as cerebral infarction,infarct area located in lobes(frontal lobe and parietal lobe),basal ganglia,brainstem and cerebellum,thus it can be seen the infarct area can located in any part of the brain infarcts.In 23 hemorrhagic cerebrovascular disease patients there are 13 ventricular hemorrhage,in which 5 patients with parenchymal hemorrhage,2 patients with subarachnoid hemorrhage;There are 8 subarachn oid hemorrhage,in addition to the two patients to merge ventricular hemorrhage(2),1 with parenchymal hemorrhage,5 only performance for subarachnoid hemorrh age;Another four patients bleeding alone located in the brain parenchyma.6 pati ents,blooding areas located in the basal ganglia region,5 persons located in the cerebral lobe(3),through the above data we can see that the proportion of ventr icular hemorrhage and subarachnoid hemorrhages is higher than pure parenchymal hemorrhage,and the parenchymal hemorrhage can also be located in the basal ganglia region and the lobes.Cerebral imaging examination results: a total of 20 internal carotid artery involve ment,10 narrow,10 block;35 middle cerebral artery involvement,12 narrow,23 block;26 anterior cerebral artery involvement,3 narrow,23 block;Also fou nd two patients with posterior circulation stenosis,7 patients with intracranial an eurysms.32 patients with smoke vascular,6 cases use anterior communicating arte ry,15 cases use posterior communicating artery,10 cases through the deep match of perforating artery with anterior circulation and the posterior circulation loop;3 cases use ophthalmic artery compensatory pump blood(1).Conclusion: Moyamoya disease has various clinical manifestations and lack of specificity,and can lead to the neurologic impairment symptoms such as hemiplegi a,aphasia,nonspecific symptoms such as headaches and the cognitive dysfunctio n DSA is the "gold standard" to diagnosis the disease,and now with the deepen ing understanding of the disease and MRA examination technology widespread a pplication and the improvement of accuracy,the diagnosis of this disease also have obvious improvement.