Atorvastatin Calcium In Elderly Patients With Chronic Heart Failure Inflammatory Damage Intervention Study

Objective:Observation of atorvastatin calcium on elderly patients with chronic heart failure of inflammatory markers high-sensitivity c-reactive protein(hs-CRP),tumor necrosis factor-(TNF-a),interleukin 6(IL 6)and the influence of cardiac function and structure,research of statins in the treatment of elderly patients with chronic heart failure function and mechanism,to explore new methods of treatment of heart failure.Methods: Choice between January 2014 and October 2014 hospitalized in our hospital into standard NYHA Ⅲ-level in elderly patients with chronic heart failure,70 cases Ⅳin our hospital and the healthy check-up of 30 cases(control group)as the research object,the elderly patients with heart failure were randomly divided into conventional treatment group and routine treatment with atorvastatin calcium treatment group 35 examples,measured by radioimmunity method,two groups of serum high-sensitivity creactive protein(hs-CRP),tumor necrosis factor-(TNF-a),interleukin 6(IL-6)level,the echocardiographic diagnostic instrument(Philips i E33 ultrasound system,and probe the S5-1)measure the observation groups before treatment and after treatment of left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),enzyme league immune method for determination of BNP values.Application of statistical methods for data analysis and processing.By comparing the conventional heart failure treatment namely diuretics(cefuroxime Sammy united spironolactone),aldosterone receptor antagonist,beta blockers,digitalis preparations,etc,and on the basis of conventional treatment combined with atorvastatin treatment on serum immune inflammatory markers in elderly patients with chronic heart failure and cardiac structure and function of new treatment method to explore the influence of heart failure.Results:Elderly patients with chronic heart failure the hs CRP,serum TNF-a,IL-6 higher than the control group obviously.Atorvastatin treatment group after treatment the blood hs-CRP,TNF-a,IL-6 levels after treatment than before treatment and routine treatment group were reduced.Atorvastatin treatment group left ventricular enddiastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),BNP values from this group before and conventional treatment group after treatment were significantly decreased,atorvastatin treatment group after treatment of left ventricular ejection fraction(LVEF)before a group therapy and conventional treatment group were significantly increased after treatment.Conclusion: Exist immune activation of patients with chronic heart failure and myocardial inflammation,hs CRP,serum TNF-a,IL-6 increased obviously,and the correlation with the heart function,on the basis of conventional treatment combined with atorvastatin can obviously inhibit the immune inflammatory lesions of patients with heart failure,reduce ventricular remodeling and improve cardiac function.Can be used as a new method for treatment of heart failure patients.