Research And Development Of CAD/CAM System Of 3D Printing For Biomaterials

With the rapid development of modern industrial and manufacturing,the technology of3 D printing has been rapid development in the field of rapid prototyping,and has been widely used in the field of rapid prototyping.At present,the technology of 3D has been successfully applied in the industrial design,automobile manufacturing,aeronautics and astronautics,building,dental and other all fields.Recently,many research institutions have been doing some researching about 3D printing of biomaterials.At present,the application field of 3D printing of biomaterials is mainly for tissue engineering scaffolds.This will provide certain theoretical basis for the 3D printing of cells,tissue and organs manufacturing subsequently.Hydrogel materials and forming processes have a significant impact on the performance of tissue engineering scaffolds and cell 3D printing.Scaffolds supports cell adhesion as a temporary extracellular matrix,which plays a key role in tissue engineering and regenerative medicine.Hydrogel 3D structure bio-fabrication is an important step towards cell 3D printing.A precision extrusion nozzle based on ball screw transmission was developed for hydrogel fabrication.Porous Gelatin-Sodium alginate hydrogel scaffolds were fabricated by low-temperature 3D printing.The whole bio-fabrication temperature was controlled between4-14°C which eliminates ice exactly.Three-dimensional structure was formed based on the temperature-sensitive gelling properties of gelatin.The concentration of sodium alginate was very critical for scaffolds forming,it increased the viscosity of the gelatin solution,while solid the three-dimensional structure by crosslinking in calcium chloride solution.Hereby,the influence of the hydrogel concentration,the extrusion speed and scanning speed,the printing temperature,scanning spacing and the heights of layer were analyzed in depth.As a result,hydrogel scaffolds could be designed having a 100% interconnected pore network in the gelatin concentration range of 10% and the sodium alginate concentration range of 2%.Through the experiments and the improvements of parameters of processing.The processing parameters of this paper can be directly applied to hybrid printing of hydrogel material,cell,tissue and organs manufacturing...