The Correlation Of 25-hydroxy VitaminD₃ And Insulin Resistance With Papillary Thyroid Carcinoma

Object:This study aims to investigate the correlation of 25-hydroxyvitamin D₃ and insulin resistance with papillary thyroid carcinoma. Method:Randomly select 358 patients diagnosised with PTC during 2014.9-2015.9 in the First Affiliated Hospital of Zhengzhou university as observation group.The control group consists of 290 healthy volunteers. Detect the 25-hydoxy vitamin D₃、fasting blood glucose、fasting insulin of all the members and explore the relationship between 25-hydroxyvitamin D₃、insulin resistance and expression of BRAFV600 E 、lymph node metastasis in PTC. Results:（1） Comparison between PTC and the normal control group:the 25-hydoxy vitamin D₃ concentration in PTC（15.8±5.00）（ng/ml）was significantly lower（P=0.000）than the control（19.1±5.66）（ng/ml）; the IRI in PTC（1.03±0.220）was significantly higher（P=0.000）than the control（0.965±0.187）;（2） Comparison between PTC with and without lymph node metastasis: the 25-hydoxy vitamin D₃ concentration in PTC with lymph node metastasis（13.3±4.68）（ng/ml）was significantly lower（P=0.000）than the PTC without lymph node metastasis（16.7±4.82）（ng/ml）; the IRI in PTC with lymph node metastasis（1.18±0.191）was significantly higher（P=0.000）than the PTC without lymph node metastasis（0.985±0.207）; the age in PTC with lymph node metastasis（40.4±13.0）was significantly lower（P=0.002）than the PTC without lymph node metastasis（45.2±11.1）.（3） Comparison between PTC with and without BRAF genetic mutation: the 25-hydoxy vitamin D₃ concentration in PTC with BRAF genetic mutation（15.3±4.91）（ng/ml）was significantly lower（P=0.000）than the PTC without BRAF genetic mutation（18.6±4.52）（ng/ml）; the IRI in PTC with BRAF genetic mutation（1.08±0.196）was significantly higher（P=0.000）than the PTC without BRAF genetic mutation（0.809±0.199）; there was no significant difference between two groups of age.（4） Binary logistic regression analysis showed insulin resistance and female were risk factors of PTC,while 25-hydoxy vitamin D₃ was protective factor. Conclusion:25-hydoxy vitamin D₃ may be a protective factor for PTC. Improving the insulin sensitivity may help prevent the occurrence and development of PTC.