Neonatal Necrotizing Enterocolitis Risk Factors And IL-8,IL11,CD14 Impact On Surgical Outcomes

Objective: To study neonatal necrotizing enterocolitis risk factors and IL-8,IL11,CD14 impact on surgical outcomes.Methods: During June 2013 to May 2014,collecting 53 cases of children with NEC as observation group in our hospital,in addition to choose born during the same period in neonatal intensive care unit from our hospital 61 cases of NEC children as control group.The clinical data of two groups of subjects to take the form of questionnaires are collected,According to the state of children and children with bowel disease in selecting operation mode.Observe all the object of gender,acidosis,hypercapnia,childbirth way,respiratory distress syndrome,hypokalemia,premature rupture of amniotic membrane,infection,gestational hypertension,hypoxemia,intrapartum asphyxia,respiratory failure,pneumonia,after the birth of oxygen,septic shock,sepsis,diffuse intravascular coagulation,hypocalcemia,hyponatremia,birth weight,gestational age,corticosteroids,high bilirubin hematic disease,before the onset of lactation,prior to taking probiotics.Variables was statistically significant for screening,further Logistic regression analysis.Before and after the treatment,compare observation group and control group’s IL 8,IL-11,CD14 levels.Results: Both groups of gender,acidosis,hypercapnia,childbirth way,hypokalemia,respiratory distress syndrome,infection clinical data is no significant difference(P >0.05),observation group of premature rupture of amniotic membrane,gestational hypertension,hypoxemia,intrapartum asphyxia,respiratory failure,aspiration pneumonia,after the birth of oxygen,septic shock,sepsis,diffuse intravascular coagulation,hypocalcemia,the incidence rate of hyponatremia is significantly higher than control group,the difference was statistically significant(P < 0.05),the observation group of children with birth weight and gestational age was significantly lower than control group,he difference was statistically significant(P < 0.05),but the observation group of prenatal use of glucocorticoid,high blood bilirubin,before the onset of lactation,the probability of disease before taking probiotics significantly lower than that of control group,he difference was statistically significant(P < 0.05).Through the project of the above have difference to pay multiariable Logistic regression analysis,found that aspiration pneumonia,sepsis,intrapartum asphyxia,respiratory failure,aspiration pneumonia,after the birth of oxygen,septic shock,sepsis,diffuse intravascular coagulation,hypocalcemia,hyponatremia,low birth weight,gestational age,hypoxemia,premature rupture of amniotic membrane,gestational hypertension belongs to the pathogenesis of NEC risk factors using glucocorticoid(or=3.243,7.723,3.246,3.154,2.345,2.687,3.215,5.321,4.211,3.212,2.421,2.143,1.943,2.965),the application of probiotics and high bilirubin levels,as NEC protection factors of the disease(or=0.089,0.067,0.053,0.211).Observation group with IL-8,IL-11,CD14 were significantly higher than control group,respectively was[(256.54±21.43)pg/ml vs(148.98±14.87)pg/ml,(95.32±9.57)pg/ml vs(82.67±19.12)pg/ml,(15.54±2.13)% vs(10.76±1.31)%](P < 0.05),after treatment,the observation group of IL 8,IL-11,CD14 levels significantly lower than before treatment,he difference was statistically significant(P < 0.05),after treatment,observation group of IL 8,IL-11,CD14 level was significantly reduced(P < 0.05).The observation group of IL-8(152.32±15.21)pg/ml,IL-11(84.43±8.78)pg/ml,CD14(10.87±1.34)% level,compared with control group had no significant difference(P > 0.05).Conclusion: Aspiration pneumonia,sepsis,intrapartum asphyxia,respiratory failure,aspiration pneumonia,after the birth of oxygen,septic shock,sepsis,diffuse intravascular coagulation,hypocalcemia,hyponatremia,low birth weight,gestational age,hypoxemia,premature rupture of amniotic membrane,gestational hypertension belongs to the pathogenesis of NEC risk factors using glucocorticoid,the application of probiotics and high bilirubin levels,as NEC disease protection factors.IL-8,IL-11,CD14 indicators will be obvious influence on the prognosis of surgery sexual function.