Clinical Research On The Effect Of Xuandan Sanjie Detection On Treating The Stagnancy Of Qi And Blood Stasis Type Of Adenomyosis

Objective:To evaluate the clinical effects of XuandanSanjie Decoction combined with Mirena on the Qi stagnation and blood stasis type of adenomyosis by observing the changes of dysmenorrhea, menstrual blood volume,traditional Chinese medicine syndrome,total therapeutic effect, uterine endometrium spiral artery resistance index, serum CA125 values,and serum hormone level changes before and after the treatment, and adverse drug reaction.To objectively evaluate the clinical effects of XuandanSanjie Decoction on the Qi stagnation and blood stasis type of adenomyosis, and the basis for the clinical treatment of XuandanSanjie Decoction on Qi stagnation and blood stasis type of adenomyosis was provided.Methods:One hundred and eight cases that were diagnosed as the Qi stagnation and blood stasis type of adenomyosis were randomly assigned into three groups, thirty eight cases for the traditional Chinese medicine group, took XuandanSanjie Decoction; thirty six cases for the Mirena group, inserted intrauterine device of Mirena; thirty four cases for the combination group, who inserted intrauterine device of Mirena and took XuandanSanjie Decoction after the menstrual period. All of them treated for three momths. The changes of dysmenorrhea, menstrual blood volume, traditional Chinese medicine syndrome, total therapeutic effect, uterine endometrium spiral artery resistance index, serum CA125 values, and serum hormone level before and after the treatment were observed, the adverse drug reaction and security were observed also.Results:(1) Dysmenorrhea efficacy evaluation:the dysmenorrhea symptom scores after the treatment were significant lower than those before the treatment in the three treatment groups (P <0.05).There were significant difference between combination group and traditional Chinese medicine group, combination group and Mirena group after the treatment (P<0.05).But after the treatment, there were no significant differences of the dysmenorrhea symptom scores between the traditional Chinese medicine group and Mirena group (P>0.05). (2) Menstrual blood volume efficacy evaluation:the menstrual blood volume scores after the treatment were significant lower than those before the treatment in the three treatment groups (P<0.05). There were significant difference between combination group and traditional Chinese medicine group, combination group and Mirena group after the treatment (P<0.05). After the treatment, there were also significant differences of the menstrual blood volume scores between the traditional Chinese medicine group and Mirena group (P<0.05). (3) The traditional Chinese medicine symptom efficacy evaluation:The traditional Chinese medicine symptom scores after the treatment were significant lower than those before the treatment in the three groups (P<0.05). There were significant difference between combination group and traditional Chinese medicine group, combination group and Mirena group after the treatment (P<0.05). After the treatment, there were also significant differences of the menstrual blood volume scores between the traditional Chinese medicine group and Mirena group (P<0.05). (4) The total therapeutic effect evaluation:the total efficiency of the traditional Chinese medicine group, Mirena group and the combination group were 60.00%,70.00% and 76.67%.There were significant difference of the total efficiency among the three groups(P<0.05). (5) The uterine endometrium spiral artery resistance index evaluation:The uterine size was reduced of the three groups in different degrees, the vuterine endometrium spiral artery resistance index rosed,which were significantly different after the treatment(P<0.05).But there were no significant difference among three groups after the treatment(P>0.05). (6) The comparison of CA125 values among three groups:the CA125 values after the treatment were significant lower than those before the treatment in three groups (P<0.05). There were no significant differences of the CA125 values among the three groups after the treatment (P>0.05). (7) The comparison of Hormone levels:There were no significant differences of the E2、FSH、LH、PRL、FT3、FT4、TSH levels among the three groups after the treatment (P>0.05). There were no significant differences of Hormone levels among the three groups after the treatment (P>0.05). (8) The safety comparison:Chinese traditional medicine group has the lowest incidence of adverse reactions, combination group has the secondly low incidence, while the Mirena group has the highest incidence, the combination of Mirena and XuandanSanjie Decoction can effectively reduce the incidence of adverse reactions after treatment.Conclusion:XuandanSanjie Decoction can improve the dysmenorrhea symptom menstrual blood volume and traditional Chinese medicine syndrome,reduce the uterine size, lighter congestion, reduce the serum CA125 values, have good total therapeutic effect. The improvement of dysmenorrhea and menstrual quantity in Mirena group is superior to the traditional Chinese medicine group. The improvement of traditional Chinese medicine symptom in traditional Chinese medicine group Group is superior to Mirena group. The treatment of XuandanSanjie Decoction combined with Mirena on Qi stagnation and blood stasis type of adenomyosis is certain,and the combined Chinese and western medicine therapy can effectively reduce the adverse drug reactions of Mirena group, obtain a better curative effect than Mirena or Chinese medicine alone.