Efficacy Of Irbesartan Hydrochlorothiazide On Elderly Isolated Systolic Hypertension Patients And Effect On CIMT And Plasma Hs-CRP Level

Objective: To study the antihypertensive effect of Irbesartan Hydrochlorothiazide on elderly patients isolated systolic hypertension and the effect on vascular remodeling and inflammatory.Methods: To Select the data of 100 cases of elderly patients with isolated systolic hypertension which comformed to the diagnostic criteria for analysis from January 2014 to December 2014. Firstly, 100 cases were divided into two groups in equal amounts according to the random number method.Secondly, the control group had taken the nifedipine antihypertensive medication to treat for 6 months,while the treatment group had taken the irbesartan hydrochlorothiazide therapy to treat for 6 months. Finally,24 h ambulatory blood pressure(ABPM), carotid intima-media thickness(cIMT), High sensitive creactiveprotein(hs-CRP) and other indicators were compared before and after treatment. The data were statistically analyzed by SPSS13.0 software.Results: 1.Two groups of patients' 24 h ambulatory blood pressure related indicators' diffenrence before treatment, such as 24-hour average systolic blood pressure(24h SBP), average daytime systolic blood pressure(dSBP), average nighttime systolic blood pressure(nSBP), 24 hSBP load value, 24-hour average diastolic blood pressure(24hDBP), average daytime DBP(dDBP), average nighttime diastolic blood pressure(nDBP) and 24-hour average pulse pressure(24hPP),were not statistically significant(P> 0.05); Two groups of patients' 24 hSBP, dSBP, nSBP, 24 hSBP load value, 24 hDBP, dDBP, nDBP and 24-hour mean pulse pressure were significantly lower than prior treatment(P <0.05); After treatment,the treatment group's 24 hSBP, dSBP, nSBP, 24 hSBP load value and 24 hours the average pulse pressure were significantly lower than the control group(P <0.05), and two groups' 24 hDBP, dDBP, nDBP difference were not statistically significant(P> 0.05);The treatment group's total effective rate was 92%,while the control group's total efficiency was 74%, and the total efficiency of the two groups had significant difference(P <0.05); The treatment group's T / P(T / P) ratio, smoothness index(SI) were significantly higher than the control group.2. Two groups of patients' carotid intima-media thickness(c IMT) and ultra-sensitive CRP(hS-CRP) index difference were not statistically significant before treatment(P> 0.05); The treatment group's therapy carotid intima-media thickness(cIMT) and ultra-sensitive CRP(hS-CRP) targets were significantly lower than the control group after treatment(P <0.05).Conclusion: 1. Elderly patients with isolated systolic hypertension can obtain good antihypertensive effect by using Irbesartan Hydrochlorothiazide and nifedipine,but antihypertensive effect of Irbesartan Hydrochlorothiazide is more stable and has less adverse reactions.2.Irbesartan Hydrochlorothiazide can significantly reduce the thickness of carotid intima-media of elderly patients isolated systolic hypertension and can reduce the level of hs-CRP, have the effect of reversing vascular remodeling and anti-inflammatory.