The Application Research Of Mri-based Brain Atrophy And Lesions Index In Evaluation Of Mild Cognitive Impairment In Type 2 Diabetes Mellitus

Objective: a variety of brain structural changes associated with aging and type 2 diabetes mellitus. The purpose of this study is to explore the performance of brain atrophy and lesions index in predict of mild cognitive impairment in type 2 diabetes mellitus.Materials and Methods: This study sequentially collected 88 cases in our hospital outpatient and inpatient department from January 2014 to January 2016. The clinical data of patients been collected, All patients carry out Mo CA and MMSE cognitive scoring, and according to the MMSE scores to divided patients into mild cognitive impairment group(n=23) and cognitive normal group(n=65). All patients were finished high resolution 3.0T magnetic resonance imaging scan.Comparisons of the mean values of the BALI total scores and the sub-scores by diagnostic groups conducted using one-way ANOVA.Using nonparametric test to detect cognitive demographic characteristics of different groups and the presence of diabetes group. Pearson correlation coefficient to assess the relationship between BALI scores and age, MMSE scores. Using Spearman correlation coefficient to detect the relationship between BALI scores and diagnostic groups. Receiver operating characteristic analysis(ROC) and Sensitivity analysis was used to examine the performance of BALI.Results: T1 WI and T2 WI based BALI scores showed a linear correlation(r = 0.93, P <0.001). The mean values of BALI total scores and sub-scores of mild cognitive impairment group were higher than control group, and except for BG, IT group, other sub-scores have statistically difference. Sex and education degree have no statistically difference between diagnostic groups, but Mo CA scores and age have statistically difference(P<0.05). cognitive scores and BALI scores have statistically difference between diabetic and non-diabetic group. Different types of images BALI scores correlated with age(r = 0.516, P <0.001).Specificity of T1 WI and T2 WI based BALI scores were 81.5%, and66.2%, Sensitivity were 56.5%, 69.6%. The area under the ROC curve was 0.71(T1WI), 0.72(T2WI).Conclusion: Multiple structural changes in brain have an additive effect on cognition and can be collectively evaluated by use of the BALI total score. BALI scores have potentiality for predict mild cognitive impairment in type 2 diabetes mellitus.