The Clinical Study Of Zishen ShuKun Decoction In Treating The Mood Disorder Which Belong To The Menopausal Syndrome Caused By Kidney Deficiency And Liver Stagnation

Objective: To Observe The clinical study of Zishen ShuKun decoction in treating the mood disorder which belong to the the menopausal syndrome caused by kidney deficiency and liver stagnation and act as anxiety and depressive.Method:60 patients were divide randomly into test group(30 cases, treated with ZSSKD) and control group(30 cases, treated with LiweiAi capsule). Before and after treatment, observe the improvement on the clinical symptoms,physical signs and and determine the changes of serum E2,5-HT, NE and the thickness of endometrium. After treatment the differences between the test and control groups are observed.Result: After the treatment,both the Kupperman points and the SAS, SDS, TCM symptom scores of the treat group and control group are lowered.The differences are significant before and after treatment(P < 0.01). The differences between the two groups are statistically significant(P <0.05);After treatment, Comparing with the before treatment, E2 is raised and NE,5-HT are reduced(P<0.01). And there is little changes in the thickness of endometrium(P > 0.05).Compared with the control group, there are statistically significant differences in the,5-HT, NE and the thickness of endometrium(P<0.05), And there is little changes in the E2(P>0.05).Conclusion: Compareing with estrogen,ZSSKD is more effective in treating the mood disorder which belong to the the menopausal syndrome caused by kidney deficiency and liver stagnation and act as anxiety and depressive. The effect may be achieved through adjusting the serum E2,5-HT, NE level regulating Neuroendocrine system and central nervous system to improve syndrome and reducing the side effects of drug therapy.