Study On Medication Rule Of Professor Mao Dexi In Treating Epigastric Fullness Based On Data Mining Technology

Objective: Use TCMISS(Traditional Chinese Medicine Inheritance Support System)V2.0.1 to analyze the data on professor Mao Dexi’s prescription of treating Epigastric Fullness and dig the mediation rule based on data mining technology,make a more perfect summary of famous old Chinese doctors’ experiences,provide a new way of thinking and reference for the clinical treatment of Epigastric Fullness,promote to develop new prescriptions and spread famous old Chinese doctors’ thoughts.Methods: Collect prescriptions of treating Epig astric Fullness from Professor Mao Dexi when he worked in the Henan Province hospital of TCM(Henan University of Chinese Medicine;the Second Affiliated Hospital)in 1992-2016,put the data into TCMISS,use Association Rules Analysis,Entropy clustering,Improved mutual information method and hierarchical cluster analysis integrated in TCMISS for data mining.After analyzing the frequency and correlation of the drug used in treating Epigastric Fullness by professor Mao Dexi,get preliminary core pharmaceutical composition and Selection of new prescriptions.Results: Use Hierarchical clustering analysis method and others in TCMISS to analyze the 909 prescriptions of professor Mao Dexi treating Epigastric fullness,The results are as follows:1.Sorted by frequency in descending of all medications,in the top 20 medications are: Radix glycyrrhizae,Amomi fructus,pinelliae rhizoma praeparatum cum alumine,Agastache rugosa,Eupatorium fortunei Turcz,Coptis rhizoma,Euodia rutaecarpa,Citrus aurantium L.,Citri reticulatae pericarpium,Setariae fructus germinatus,Hordei fructus germinatus,Codonopsis radix,Chinese fevervine herb and root,scutellariae radix,Magnoliae officinalis flos,Zingiberis rhizoma,Atractylodis macrocephalae rhizoma,Bupleuri radix,Poria,Fritillariae thunbergii bulbus.2.Frequently used 10 couplet medicines combinations:(1)Friture Hordei fructus germinatust,Hordei fructus germinatust;(2)Coptis rhizoma,Euodia rutaecarpa;(3)Friture Hordei fructus germinatust,Setariae fructus germinatus;(4)Euodia rutaecarpa,Amomi fructus;(5)Dioscoreae rhizoma,Stegt crataegi fructus;(6)Bupleuri radix,pinelliae rhizoma praeparatum cum alumine;(7)Dioscoreae rhizoma,Myristicae semen;(8)Coicis semen,Friture Coicis semen;(9)Agastache rugosa,Eupatorium fortunei Turcz;(10)Magnoliae officinalis flos,Citrus aurantium L.3.Three medications combinations:(1)Amomi fructus,Coptis rhizoma,Radix glycyrrhizae;(2)pinelliae rhizoma praeparatum cum alumine,Amomi fructus,Radix glycyrrhizae;(3)Coicis semen,Magnoliae officinalis flos,White Chrysanthemum;(4)Euodia rutaecarpa,Amomi fructus,Radix glycyrrhizae;(5)Amomi fructus,Agastache rugosa,Radix glycyrrhizae;(6)Amomi fructus,scutellariae radix,Ophiopogonis radix;(7)pinelliae rhizoma praeparatum cum alumine,Coptis rhizoma,Radix glycyrrhizae;(8)Euodia rutaecarpa,Coptis rhizoma,Radix glycyrrhizae;(9)pinelliae rhizoma praeparatum cum alumine,Euodia rutaecarpa,Radix glycyrrhizae;(10)pinelliae rhizoma praeparatum cum alumine,Agastache rugosa,Radix glycyrrhizae;(11)Eupatorium fortunei Turcz,Agastache rugosa,Radix glycyrrhizae;(12)pinelliae rhizoma praeparatum cum alumine,Amomi fructus,Coptis rhizoma;(13)Euodia rutaecarpa,Amomi fructus,Coptis rhizoma;(14)pinelliae rhizoma praeparatum cum alumine,Amomi fructus,Agastache rugosa;(15)Eupatorium fortunei Turcz,Amomi fructus,Agastache rugosa.4.New prescriptions combinations:(1)Sepiae endoconcha,Concha arcae,Fritillariae thunbergii bulbus,Paeoniae radix rubra,Friture armeniacae semen amarum;(2)Setariae fructus germinatus,Dioscoreae rhizoma,Hordei fructus germinatus,Oryzae fructus germinatus;(3)Poria cum Radix Pini,Acori tatarinowii rhizoma,Ziziphi spinosae semen,Polygalae radix;(4)Santali albi lignum,Linderae radix,Lilii bulbus,Toosendan fructus;(5)Lycii fructus,White Chrysanthemum,Leonuri fructus,Buddlejae flos;(6)scutellariae radix,Coptis rhizoma,Citri reticulatae pericarpium,Euodia rutaecarpa,Bupleuri radixi;(7)Atractylodis macrocephalae rhizoma,Cassiae semen,Cannabis fructus,Eucommiae folium;(8)Lablab semen album,Dioscoreae rhizoma,Nelumbinis semen,Myristicae semen;(9)Astragali radix,Paeoniae radix alba praeparata cum melle,Cinnamomi ramulus,Astragali radix praeparata cum melle;(10)Polygonati odorati rhizoma,Viticis fructus,Pharbitidis semen,Angelicae dahuricae radix,Benincasae exocarpium;(11)Paeoniae radix alba praeparata cum melle,Bupleuri radixi,Astragali radix praeparata cum melle,Aurantii fructus;(12)Corydalis rhizoma,Faeces Trogopterpri,Cyperi rhizoma,retinervus Citri Fructus;(13)Polygoni multiflori caulis,Cinnamomi cortex,Prunellae spica,Anemarrhenae rhizoma;(14)Scrophulariae radix,Ostreae concha,retinervus Citri Fructus,Scutellariae barbatae herba;(15)Nelumbinis plumula,Triticum aestivum L.,Moutan cortex,Lophatheri herba,Lycii cortex;(16)Triticum aestivum L.,Moutan cortex,Gardeniae fructus,Leonuri herba;(17)Salviae miltiorrhizae radix et rhizoma,Rosae rugosae flos,Ganoderma,Leonuri herba;(18)Scutellariae radix,Agastache rugosa,Poria,Zingiberis rhizoma,Codonopsis radix,pinelliae rhizoma praeparatum cum alumine;(19)Agastache rugosa,Eupatorium fortunei Turcz,Poria,Zingiberis rhizoma,Codonopsis radix,pinelliae rhizoma praeparatum cum alumine.Conclusion:Get the following conclusions through the research of this topic:1.Professor Mao Dexi has rich experience in treating Epigastric Fullness,his medication prescription is worth to be dug deeply,research of medication rule has a huge value for guidance in the clinical treatment of Epigastric Fullness based on data mining technology.2.Through analyzing the prescription of professor Mao Dexi in treating Epigastric Fullness,it shows that Mao Dexi mainly uses some kinds of prescription drugs,such as aromatic turbidity,clearing heat and dampness,strengthen spleen and stomach,promoting qi circulation and relieving depression and so on.The test results conform to the characteristic of professor Mao in Traditional Chinese medicine.3.The method of combining data mining technology in TCMISS and manual collection will be very helpful for summarizing famous old doctors’ traditional Chinese medicine clinical experience.4.The core pharmaceutical combination and new prescription found based on data mining provide an important basis for clinical treatment and fundamental research,it’s beneficial to the spread of the famous old Chinese doctor’s thoughts and clinical experience.