| OBJECTIVE: To set the standard values and correct values of antibiotic utilization ratio,antibiotic use intensity and the antibiotic evaluation standard of Endocrinology. And then the each link of antibiotic drug used by Endocrinology, providing the basis of the rational use and the scientific management of antibiotics in Endocrinology.METHODS: Collecting antibiotic materials of Endocrinology at home and abroad, the antibiotic clinical specification of Endocrinology was formulated, which included 9 kinds of respiratory infectious disease, infectious disease 5 kinds of urinary system, digestive system 4kinds of infectious disease, skin and soft tissue infection 5 kinds of, other infectious diseases, the empiric antibiotic therapy for Endocrinology infectious diseases and the rational utilization for special crowd.Extracting the discharged patients cases of orthopedic from Jan. to Dec. 2014 from a third class A hospital in Fujian province, a total of 1351 cases were collected: 751 male and 600 female, age range of 3 to 90 years old and average hospitalization days of 10.46 d,29 kinds of diseases were got, which related to diabetes(type 1 and type 2), Systemic lupus erythematosus(SLE), etc. 26 kinds of infectious diseases are among those, a total of 435 cases.RESULTS: Retrospective research endocrinologist antimicrobial drug use situation, the antibiotic utilization ratio and antibiotic use intensity, which was33.99%,100 person day 56.34DDDs; According to the antibiotic clinical specification of Endocrinology, the standard value of antibiotic utilization ratio and antibiotic use intensity was respectively 27.60%, 100 person day22.66 ~ 35.32 DDDs. According to the Endocrinology clinical application of antibacterial drugs specification, based on 2014 discharged patients 1351 cases for analysis, the reason of Endocrinology of antimicrobial agents application index actual values on the high side is the patient with no against use of antimicrobial agents,treatment for too long,combination and replacement drugs is not reasonable,single drug dosage and dosing frequency is not reasonable,hepatic and renal dysfunction, dose not adjust the dosage as the rules. Researching retrospectively the situation of antibiotic utilization control indicators in Endocrinology, the actual value ofantibiotic utilization ratio and antibiotic use intensity, which was 29.27%,100 person day 40.28 DDDs.Tthe standard value of antibiotic utilization ratio and correction is equal, antibiotic use intensity is slightly lower than the theoretical value of correction,in infectious diseases to drug treatment, drug combination and replaced, to the condition of patients develop individualized dosage regimen.With SPSS software for statistical analysis. It was concluded that there was a significant difference between the actual usage rate and the correction value of the antimicrobial agents in Endocrinology(2c=7.013,P<0.05), antibiotic use intensity were also statistically different(Z=-1.573,P<0.001).CONCLUSIONS: According to the antibiotic clinical specification and the antibiotic evaluation standard of Endocrinology, every link of antibiotic utilization in orthopedic was evaluated. The unreasonable elements of antibiotics utilization in Endocrinology were mainly manifested in ten aspects, which were respectively 86 no indication of antibiotics, 63 selected antibiotics, 41 course of treatment, route of administration unreasonable 29 cases,30 combination therapy,62 switch other drug, incompatibility 64 cases, 32 dosage of antibiotics, 23 dosing frequency, which indicated that the phenomenon of irrational use of antibiotics in Endocrinology was widespread and serious, and there were many problems needed to be tackled urgently. |
PDF Full Text Request