The Resting-state Functional Magnetic Resonance Imaging Study Of Default-mode Network In Type 2 Diabetes Mellitus

ObjectivesUsing independent component analysis to explore aberrant function connectivity within default-mode network(DMN) in type 2 diabetes mellitus patients.To analysis the correlation between network abnormalities and clinical parameters in T2 DM patients.and then make known the relationship between them. MethodsThe MRI data were recorded in 23 patients with T2 DM and 20 health control subjects by a Siemens Trio 3.0 T MR scanner,include T2WI、DWI、3D-T1 WI and RS-fMRI. Montreal Cognitive Assessment was applied to assess the level of cognitive in all subjects.Mini-mental State Examination also was performed.All clinical parameters were recorded accurately. Independent component analysis was adopted to extract the default-mode network.Z-maps of default-mode network were compared between the two groups and correlated with each clinical parameters by SPSS 20.0 packages. Results1.Compared with healthy controls(P<0.05), T2 DM patients showed significantly decreased Z value in the right medial prefrontal cortex(MPFC) posterior cingulate cortex(PCC) and left precuneus.2.The decreased connectivity in the DMN was no significantly correlation with disease duration、HbA1c、MMSE and MoCA. Conclusion1.There was aberrant function connectivity of default-mode network in T2 DM patients,it main be the neuropathologic mechanism that underlie the diabetes-related cognitive decline.2.The aberrant function connectivity of default-mode network in T2 DM patients mainly lay in cerebral areas related with memory,it indicates that the main early cognitive impairment may be memory loss.3.RS-fMRI might be a new potential tools to monitior the change of cognition in T2 DM patients.It might benefit the early diagnosis of diabetic encephalopathy and show down the progress of the desease.