| Objective: To investigate the activation of PTEN,PI3K/Akt/mTOR signal pathway in mantle cell lymphoma and its association with clinicopathologic characteristics.Materials and Methods:15 cases of mantle cell lymphoma and 20 cases of reactive lymphoid hyperplasia were collected from Department of Pathology of this hospital from January 2005 to March 2015.All the cases were classified and diagnosed by the Senior pathologists. Then,the technology of immunochemistery were applied to analysis the expression of pAkt,pmTOR,pRPS6 and PTEN in 15 cases of mantle cell lymphoma and 20 cases of reactive lymphoid hyperplasia. At last,we performed SPSS13.0 sofeware to analyses the final data.Results:(1)Among 15 cases of mantle cell lymphoma,the expression rates of pAkt、pmTOR and pRPS6 were 87%(13/15), 93%(14/15),87%(13/15),respectively. The rates were significantly higher than that of reactive lymphoid hyperplasia(50%,60%,50%)(P<0.05). The expression rate of PTEN in mantle cell lymphoma was 60%(12/15)which was not lower than that of reactive lymphoid hyperplasia by technology of immunochemistery.(2) The expression level of pAkt in mantle cell lymphoma was significantly correlated with pmTOR(P<0.05);the expression level of pmTOR in mantle cell lymphoma was significantly correlated with pRPS6(P<0.05); the expression level of PTEN in mantle cell lymphoma was not significantly correlated with pAkt(P>0.05).(3) The expression of pAkt,pmTOR,PTEN and pRPS6 in mantle cell lymphoma showed no significant correlation with the patients’ gender,age, clinical stage,B symptoms,MIPI,ECOG,presence of extranodal diseases, source of lymphoma cells and serum lactate dehydrogenase values.Conclusion:The expression of PI3K/Akt/mTOR signal pathway plays an important role in the development and progression of mantle cell lymphoma,whereas that PTEN inactivation by genetic and/or epigenetic changes may contribute to Akt activation in a fraction of patients. |
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