The Distribution Of Pathogens And Risk Factors In The Inpatients With Urinary Tract Infections

Purpose: Research on the different microorganism distributions of urinary tract infections(UTIs) in patients with different risk factors or basic conditions. To provide certain scientific evidence for clinicians in empirically anti-infection treatment. Method:Choosing patients with UTIs hospitalized in Fujian Provincial Hospital from September1 st 2014 to September 30 th 2015 to collect the spectrum of urethral pathogens in different risk factors or basic conditions, respectively. Processing data with statistics software SPSS 22.0. T test for measurement data, and chi-square test for counting data.Result: 988 bacterial strains have been isolated from 802 hospitalized patients. Among them, gram negative bacteria accounted for 63.26 %(625 strains), gram positive bacteria accounted for 22.67 %(224 strains), and fungi accounted for 14.07 %(139strains). Escherichia coli was identified as the most common causative agent of UTIs(353 strains, 35.73 %), followed by Klebsiellapneumonia(K.Pneumoniae)(106 strains,10.73 %), Enterococcus faecium(100 strains, 10.12 %), Enterococcus faecalis(65strains, 6.58 %), Candida albicans(58 strains, 5.87 %), and Pseudomonas aeruginosa(50 strains, 5.06 %). The distribution of pathogens in patients with UTIs was associated with gender, diabetes mellitus, urolithiasis, indwelling catheter, cerebrovascular disease,chronic kidney disease, pulmonary infection, benign prostatic hyperplasia and stay in intensive care units(ICU)(P < 0.05). There was no obvious correlation between the spectrum of urethral microorganism with malignant tumors(P = 0.389) and post-operative(P = 0.576). The most common causative pathogens in patients hospitalized in ICU and with pulmonary infection was Enterococcus faecium.Frequency of the pathogen in these two groups was 20.9 % and 17.85 %, respectively,which was significantly higher than those in patients stay in general wards and without pulmonary infection. In addition, the isolation of Escherichia coli in patients in ICU was dramatically lower(11.44 %) than in general wards’(41.93 %). Conclusion: The primary pathogen in UTIs was gram-negative bacteria. Escherichia coli, which remains the most common urethral pathogens, followed by K.Pneumoniae. However, the most common causative pathogens in patients in ICU and with pulmonary infection were Enterococcus faecium, and the isolation of fungi was also high in these two groups. In addition, the distribution of pathogens in patients with UTIs was associated with gender,diabetes mellitus, urolithiasis, indwelling catheter, cerebrovascular disease, chronic kidney disease, pulmonary infection, benign prostatic hyperplasia and stay in ICU(P < 0.05). There was no significant correlation between the spectrum of urethral microorganism with malignant tumors and post-operative.