The Influence Of Handedness On Interhemispheric Functional Connectivity Using Resting-State FMRI

【Purpose】:Application of resting state magnetic resonance image based on the methold of voxel-mirrored homotopic connectivity(VMHC) to research the handedness influences on interhemispheric functional connectivity, and add eye movement task further observe the changes of the cerebral functional connectivity.【Method】:Recruit participants by posting notice, including 13 left-handedness(LH) and 13 mixed-handedness(MH), 24 right-handedness(RH) in the control group.Using magnetic resonance(3.0 T) to gather all participants’ resting state data(BOLD1). The eye movement task stimulus will project to MR indoor screen through E-prime2.0,the second data(BOLD2) will be collected after eye movement.On the Matlab 2012 a platform using the resting state f MRI data processing assistant DPARSF_V3. 2 to preprocess the resting state data and get z VMHC value figure, using REST software to get different brain regions of the first three groups of participants(left/ right and mixed-handedness) and the participants in each group before and after the eye movement by the z VMHC statistical tests.Regarding the different brain regions before the eye movement as the region of interest(ROI), extracting VMHC value in each ROI and do partial correlation analysis with the absolute value of handedness scores.【Results】:Compared with the VMHC values of three groups before eye movement task,there was no significant difference between left-handedness and mixed-handedness brain regions under Alphasim correction, on the basis of P<0.01;Inferior temporal gyrus and posterior central gyrus in left-handedness increased when compared with the right-handedness; Caudate nucleus in mixed-handedness increased relative to right-handedness.Compared with the eye movement task before and after the eye movement, left-handedness had no significant change, mixed-handedness was reduced in bilateral insula, while fusiform gyrus in right-hanedness was significantly reduced.About the VMHC value already extracted the different brain regions(posterior central gyrus) in left-handedness had a positive significant correlation with the absolute value of handedness scores(P<0.05).【Conclusion】:①Early left-handedness although have many habit changes in the later living life with hand, but the connection of the cerebral hemisphere hasn’t changed, the nonright-handed(left-handedness and mixed-handedness)showed more interaction then right-handedness,including bilateral inferior temporal gyrus,posterior central gyrus and caudate nucleus;①In both mixed-handedness and right-handedness were found different brain regions’(insula/fusiform gyrus) information reduced due to the eyes movement task, but found no significant change in the left-handedness;①lateralization degree of handedness have certain correlation with the communication between hemispheres in different brain regions.