Study On The Association Between Single Nucleotide Polymorphism Of Rs8192678 In PGC-1α Gene And Hypertension,Non-valvular Atrial Fibrillation

ObjectThe nuclear receptors of the co-activator 1 alpha(PGC-1 alpha) include the receptors which participates in mineral corticoid and ER involved in blood pressure regulation. PGC-1 alpha gene SNP, meanwhile, related research reveal this region is correlated with blood pressure. Hence, our research take hypertensive as experimental group and normal person as control group, rs8192678 in PGC-1 alpha gene as target gene to be selected, exploring the relation between the SNP and hypertension.Atrial fibrillation is one of the common arrhythmia clinically. Plentiful studies showed inflammatory reaction attend the progress of AF, while PGC-1alpha has an multiple action on cardiovascular and cerebrovascular diseases such as anti-Inflammatory and Anti-atherosclerosis. Domestic and overseas research has little focus on the correlation of PGC-1 alpha and AF. By means of identifying the relation of rs8192678 SNP in PGC-1 alpha and AF, we explore genetic factor of inflammatory mechanism in AF.MethodWe selected inpatients of The Second Hospital of Tianjin Medical University from 1/2015 to 1/2016. Lab 1 take 115 inpatients as experimental group who is diagnosed with hypertension according to the standard of identifying and excluding, another matched 78 patients were selected as control group. Similarly, 170 patients with AF are regarded as experimental group, another 214 patients is the control group. Inpatients were selected medical history, physical examination, blood routine examination and so on. Detected the SNP of PGC-1 alpha through blood which collected from the patient of an empty stomach more than eight hours.Results1.Hypertension group compared with the control group, the percentage of neutrophils significantly increased(P﹤0.05). The distribution difference of 3 gene types has no statistical significance, no matter it appears HBP or not and no matter the patients classification according to gender or not(P>0.05). The same situation ccured in the type 2 diabetes mellitus and coronary heart disease(P>0.05). Different genotypes compared, we can conclude there is no statistical significance in all the experimental indicators(P>0.05). After excluding the effect of coronary heart disease, or among the female population, or LDL/TG value greater than normal, the variance of gene distribution of control group, level 2 hypertension and level 3 hypertension is statistical significant(P﹤0.05). The Distribution of Heterozygote A/G in hypertension 3 is obviously more than the same in the Hypertension 2(P﹤0.05).2. Utilization rate of arrhythmia drugs of patient with paroxysmal AF and persistent AF is obviously more often than no AF(P﹤0.05). RDW-SD of persistent AF patient is obvious higher than that of paroxysmal AF and permanent AF(P﹤0.05). APTT of patient with paroxysmal AF is higher than that of no AF(P﹤0.05). BUN, CR, UA of patient with persistent AF is higher than that of patient with no AF(P﹤0.05). SLV, LA and RV of patient with persist AF is higher than that of patient with no AF(P﹤0.05), LVEF is less. In addition, LA of patient with paroxysmal AF is obvious higher than that of no AF(P﹤0.05).The distribution difference of 3 gene types has no statistical significance, no matter it appears AF, T2 DM, CHD, HBP or not(P>0.05). And the distribution difference of 3 gene types has no statistically significant among no AF, paroxysmal AF, persistent AF and permanent AF(P>0.05). Among the female patients, people who use arrhythmia drugs, and patients with hypertension level 3, type(A/A) has a higher percentage in non-paroxysmal AF(P﹤0.05). When we exclude the effect of diabetes, type(A/G) has a higher percentage in non-paroxysmal AF(P﹤0.05). Under the condition of RDW-SD<54f L or FBG < 6.2mmol/L, gene type(A/A) has a higher percentage in the patient with no AF(P﹤0.05). When HBA1 C < 6.9%, gene type(A/A)has a very high percentage in patient with AF(P﹤0.05).Conclusion1. In the female population, the dyslipidemia population and excluding the CHD population, whereas the gene SNP is relevant with the severity of hypertension.2. PGC-1α SNP is related with AF in the population suffer from hypertension level 3, using arrhythmia drugs, female population and HBA1 C normal population.