Implantation Of Mobilizable ¹²⁵I Particle Chain Coaxial Drainage Catheter For Treatment Of Malignant Obstructive Jaundice

Purpose: This study aimed to investigate the feasibility and safety of implantation of mobilizable ¹²⁵I particle chain coaxial drainage catheter in the treatment of malignant obstructive jaundice（MOJ）.Methods: Participants were assigned to receive treatment with mobilizable ¹²⁵I particle chain coaxial drainage catheter（experimental group）or a conventional PTCD（control group）.After implantation,the outcomes were measured in terms of relief of obstructive jaundice,Blood tests,change of tumor volume,survival time,complications related to the procedure.A p value of less than 0.05 indicated a significant difference.Results: Surgery was successfully performed in all patients.After 1 month,the patients of TBIL tests,DBIL tests,relief of obstructive jaundice and change of tumor volume were no statistically significant difference between the two groups（P > 0.05）,although significant difference in the Ca199 test existed between the two groups（P < 0.05）.The patients with relief of obstructive jaundice at 3and 6 month in the experimental group were 44.1%（15/34）、53.3%（16/30）,respectively.While in the control group,19.4%（6/31）,7.1%（2/28）,respectively,and the difference between the two groups was statistically significant（P < 0.05）.The patients with change of tumor volume at 3and 6 month in the experimental group were 32.4%,46.7%,respectively.While in the control group,12.9%,3.5%,respectively,and the difference between the two groups was statistically significant（P < 0.05）.The median and mean overall survivals in the experimental group were higher than those in the control group（13.79 months versus 1.49 months,10.0 months versus 0.73 months,p< 0.05）.The statistically significant difference of incidence of complications between the two groups is not existed（P>0.05）.