| Purpose: To explore the related risk factors of postmenopausal women osteoporosis,analyze the impacts of urinary calcium on the bone transition and renal tubular function of postmenopausal with osteoporosis.Method: Selecting the patients who saw a doctor in the Changhai Hospital renal medicine and rheumatism and immunology outpatient service during July 2014 to December 2016,through the form of questionnaire,to collect and record the patients’ general information,such as gender,age,height,weight,whether menopause,menopausal term,number of birth,the age of first pregnancy,PMH,surgical history,exercise conditions,sunshine time,taking drugs,history of fracture,history of smoking and drinking,lifestyle and nutrition status,etc.,Ruling out other diseases affect bone metabolism,measuring bone mineral density through dual energy X-ray,according to the diagnostic standard of osteoporosis,divided into normal bone mass group and osteoporosis group,recording patients’ bone mineral density test results,blood biochemistry,urinalysis,the urine routine and bone metabolic markers,collecting patients’ fasting urine specimens,determining fasting urinary calcium/creatinine,urine micro protein urine,etc.Through each exposure index and the single factor analysis of osteoporosis,again through Logistic regression analysis under condition of multi-factor,to obtain osteoporosis risk factors and protective factors.Then to the osteoporosis group,analyze the relationship between bone mineral density(BMD),fasting urinary calcium/creatinine and urinary N-acetyl-β-glycosidase enzymes(NAG),alkaline phosphatase(ALP)and urinary β2-microglobulin(urineβ2-MG)of researched objects in this group,and osteoporosis associated with urinary tract department calculi group and non-calculi group,comparative analysis of various indicators,then analyze the impacts of urinary calcium on the bone transition and renal tubular function of postmenopausal osteoporosis.Result: A total of 290 researched objects,including 140 patients with osteoporosis,150 patients with normal bone mass,with the increase of age,the prevalence of osteoporosis is gradually increased,and more than 70-year-old osteoporosis prevalence rate was significantly higher(P ﹤ 0.01)under the age of 60.The study found that regular exercises are protective factors of osteoporosis(OR =0.457 95% CI0.236-0.887);salt intake,protein intake,the number of reproductive and the value of urinary calcium/creatinine is the risk factor of postmenopausalosteoporosis(OR > 1).In the osteoporosis group,fasting urinary calcium/creatinine and urinary NAG(P < 0.01 r = 0.721),urine β2-MG(P < 0.01 r = 0.553),ALP(P <0.01 r = 0.886)are positively related;while the urinary calcium/creatinine,urine NAG,urine β 2-MG and ALP of osteoporosis associated with urinary tract department calculi group were higher than in non-calculi group(P ﹤ 0.05).Conclusion: Control the intake of salt and animal protein,exercise actively,strengthen the health education in postmenopausal osteoporosis;the bone absorption of osteoporosis group is higher than the normal bone mass group,and fasting urinary calcium/creatinine can be used as a risk factor for postmenopausal osteoporosis and one marker of predicting bone absorption.Among postmenopausal osteoporosis,according to the value of fasting urinary calcium/creatinine can predict bone transformation,glomerular and renal tubular function,and can also predict the risk of kidney stones. |
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