Study On The Correlation Between Traditional Chinese Medicine Syndrome Differentiation And Objective Index Of Primary Biliary Cholangitis

Objective:PrimaryBiliary Cholangitis(PBC),alias Primary Bi liary Cirrhosis(PBC),which is a kind of chronic progressive cholestatic liver diseases with Unknown etiologies.Its typical pathologies show nonsuppurative cholangitis or granulomatous cho langitis,and its mainly destroyed by small bile ductules.Its cl inical symptoms are complicated with many complications,and it will develop to hepatic failure,cirrhosis and liver cancer.PBC seriously affect the quality of life of patients even threaten life.Atpresent,western medicine treatments of this disease are limited.There is no specific treatment except UDCA.However,the traditional Chinese medicine has achieved good results in clini cal practice.Aim at distribution characteristics of TCM Syndrom es to retrospective analyze.This paper investigate the epidemio logicalfeaturesof the disease,analyze the relationship between the laboratory indexes and TCM Syndrome Types to find a feasibl e quantitative criteria for the disease and lay the foundation for further study of PBC.Methods:This research takes retrospective method to bring t he data of PBC patients which were diagnosed in the wards and s ections for outpatients of Liver Disease Research Institute of Hubei Provincial Traditional Chinese Medical Hospital from Jan.2012 to Feb.2016 into the scope of the study Organize and colle ct related indicators of those patients like gender,age,symptom s,tonguepulse,liverfunction,routine blood test and coagulation function to get TCM syndrome differentiation according to the unified standard.Summary clinical features of ascites due to cirrhosis from these data and use SPSS22.0 statistical software to deal with.In order to explore the relationship between TCM syndrome differentiation and objective indicators.Results:(1)In terms of gender composition,there are 17 male cases(25.37%),50 female cases,the ratio of male to female is 1:2.94.In terms of age distribution,the minimum age is 36 years old,the maximum age is 78 years old,the average age is 58.82±9.26;most patients are 50-59 years old,accounting for 49.25%of all cases;from large to small,the proportion of the distrib ution of each syndrome type are syndrome of stagnation of liver qi and spleen deficiency>weakness of spleen and stomach>syndrome of dampness-heat of liver and gallbladder>syndrome of yin deficiency of liver and kidney>blood stasis blocking collaterals>syndrome of yang deficiency of spleen and kidney.Study suggests that syndrome of stagnation of liver qi and spleen deficiency and weakness of spleen and stomach are prominent pathogenesis of the disease.(2)Eliminate the smallest group of weakness of spleen and stomach,this study analyze the remaining 63 cases.The level of AST between the group of syndrome of stagnation of liver qi and spleen deficiency and syndrome of dampness-heat of liver and gallbladder has statistically significant,which is considered that syndrome of dampness-heat of liver and gallbladder is higher than syndrome of stagnation of liver qi and spleen de ficiency.In all cases,TBIL of liver gallbladder damp heat type is highest,and it has statistical significance compared with liver stagnation and spleen deficiency,deficiency of liver-yin and kidney-yin and stagnation of liver-QI with deficiency of the spleen.In all cases,ALB of stagnation of liver-QI with deficien cy of the spleen is highest,and it has statistical significancecompared with syndrome of dampness-heat of liver and gallbladd er,syndrome of yang deficiency of spleen and kidney and blood stasis blocking collaterals.ALB between deficiency of liver-yin and kidney-yin and hepatochlichygropyrexia has statistically significant,which is considered that eficiency of liver-yin and kidney-yin is higher than hepatochlichygropyrexia.In all cases,H GB of stagnation of liver-QI with deficiency of the spleen is lowest,and it has statistical significance compared with stagnat ion of liver-QI with deficiency of the spleen and deficiency of liver-yin and kidney-yin.HGB of stagnation of liver-QI with d eficiency of the spleen and deficiency of liver-yin is highest,it has statistical significance compared with hepatochlichygrop yrexia,blood stasis blocking collaterals and weakness of the sp leen and the stomach.PLT of stagnation of liver-QI with deficiency of the spleen is highest,it has statistically significant compared with hepatochlichygropyrexia and weakness of the spleen and the stomach.PT of obstruction of collaterals by blood sta sis is highest in all cases,it has statistically significant co mpared with stagnation of liver-QI with deficiency of the spleen and deficiency of liver-yin and kidney-yin.Conclusion: The study has verified that there is a certain correlation between the TCM syndrome differentiation of PBC patients and the objective indicators of the laboratory like AST、A LB、TBIL、HGB、PLT、PT.It is preliminarily proved that quantifi cation of objective indicators of each PBC syndromes is feasible.And With the change of PBC type of ascites due to cirrhosis,quantitative changes of synthetic function and metabolic function of liver will occur.The degree of quantification is consistentwith the evolution of TCM Syndromes.