Clinical Randomized Controlled Observation Of TCM And Western Therapy On Post-stroke Depression Combined Sleep-disorder In Stroke Unit

Objective Comparing the clinical effect of TCM and Western Medicine on the post-stroke Depression combined sleep-disorder with TCM or Western treatment alone to find out whether the one-dose of TCM or Western single effect is less than the synergistic effect of two medical treatments;so as to discuss the therapy methods of combination of TCM and Western Medicine on the post-stroke Depression combined sleep-disorder.Methods The randomized control study was designed 180 post-stroke depression combined sleep-disorder patients were randomly assigned to treatment groups TCM and Western,TCM,Western and control.Each group has 45 cases.In stroke unit all the four groups were treated with routine treatments including anti-stroke medication,Limbs and speech rehabilitation,psychological counseling and health-education.Besides routine treatment,Tranquilization Mixture was added to TCM group,Escitalopram was added to Western group,Tranquilization Mixture and Escitalopram were added to TCM and Western group.The rating scales such as HAMD,PSQI,NIHSS,ADL were used to evaluate all patients before treatment and after 8 weeks and 24 weeks of treatment.Meanwhile,the sleep of TCM and Western group and Western group patients was assessed by PSG before treatment and after 24 weeks of treatment.Results(1)Before Treatment,the scores of HAMD,PSQI,NIHSS and ADL between four groups were no statistically significant difference(P > 0.05);(2)After 8 weeks of treatment respectively,the scores of HAMD,PSQI,NIHSS and ADL of TCM,Western,TCM and Western and control group were significantly improved with before treatment(P < 0.05);After 24 weeks of treatment respectively,the scores of HAMD,PSQI,NIHSS and ADL of TCM,Western,TCM and Western and control group were significantly improved with after 8 weeks of treatment and before treatment(P < 0.05);(3)After 8 weeks of treatment respectively,The scores of HAMD,PSQI,NIHSS and ADL of TCM,Western,TCM and Western group were statistically significant difference with control group at the same time point(P < 0.05);After 8 weeks of treatment respectively,The scores of HAMD,PSQI,NIHSS and ADL of TCM and Western group was statistically significant difference with TCM group and Western group at the same time point(P < 0.05);After 8 weeks of treatment respectively,The scores of HAMD,PSQI,NIHSS and ADL of TCM group was statistically significant difference with Western group at the same time point(P < 0.05);(4)After 24 weeks of treatment respectively,The scores of HAMD,PSQI,NIHSS and ADL of TCM,Western,TCM and Western group were statistically significant difference with control group at the same time point(P < 0.05);After 24 weeks of treatment respectively,The scores of HAMD,PSQI,NIHSS and ADL of TCM and Western group was statistically significant difference with TCM group and Western group at the same time point(P < 0.05);After 24 weeks of treatment respectively,The scores of HAMD,PSQI,NIHSS and ADL of TCM group was statistically significant difference with Western group at the same time point(P < 0.05);(5)Before Treatment,the rating scales of SL,TST,NW,SE,S3+S4%,RL and RT between TCM and Western group and Western group were no statistically significant difference(P > 0.05);(6)After 24 weeks of treatment respectively,The rating scales of TCM and Western group and Western group such as Sleep latency(SL)time,the number of Awakening(NW)and REM sleep latency time reduced,total sleep time(TST),sleep efficiency(SE),deep sleep(S3+S4%)time,and REM sleep(RT)time increased;The above indicators of two groups were statistically significant difference with before treatment(P < 0.05);The above indicators of TCM and Western group were statistically significant difference with Western group at the same time time point(P < 0.05);Conclusion TCM and Western therapy in stroke unit can effectively improve the extent of post-stroke depression combined sleep-disorder and promote neural function and activities of daily living regain.