Influence Of Optical Properties Of Port Wine Stain Phantom On Photosensizied Singlet Oxygen Luminescence

One of the most effective treatment for port wine stain （PWS） at present is vascular-targeted photodynamic therapy （V-PDT）.¹O₂ is the main biological toxicity product of II-PDT. Direct measure of ¹O₂ luminescence at 1270 nm is an important method for evaluating PDT dosimetry and it is great significance for realizing personalization therapy. It is a critical challenge for quantitative detection ¹O₂ amount, because the ¹O₂ could interacted with the absorption coefficient （μ_a）, scattering coefficient （μ_s）, and blood volume fraction （BVF） in its diffusion path. In this study, a time-resolved ¹O₂ luminescence detection system was used for studying how the optical properities influence on photosensizid ¹O₂ luminescence in homogeneous solution and PWS phantom respectively. The research indicated that the ¹O₂ luminescence intensity would be decreased by μ_a, μ_s and BVF, and there was not obviously influence of μ_a on τ_T and τ_D; τ_T was increased with μ_s, τ_D was decreased before increase with μ_s When μ_s>50 cm^-1, τ_T and τ_D seems remain the same, then τ_T=13.26 ± 0.10 μ_s, τ_D=0.86 ± 0.10 μ_s; in addition, when add BVF, there was little change of τ_T and τ_D, τ_T=12.06 ± 0.20μ_s, τ_D=0.89 ± 0.30 μ_s.